Testicular cancer pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked nuclear atypia is the characteristic finding of [[embryonal carcinoma]]; blander cytomorphology, hyaline-type globules, and schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]]; both syncytiotrophoblasts and cytotrophoblast cells is the characteristic finding of [[choriocarcinoma]]. | |||
==Pathophysiology== | ==Pathophysiology== | ||
Revision as of 14:50, 19 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of seminoma; marked nuclear atypia is the characteristic finding of embryonal carcinoma; blander cytomorphology, hyaline-type globules, and schiller-Duval bodies are characteristic findings of yolk sac tumor ; both syncytiotrophoblasts and cytotrophoblast cells is the characteristic finding of choriocarcinoma.
Pathophysiology
- More than 90% of all testicular cancers are germ cell tumors. This type of cancer starts in germ cells, which are the cells that make sperm.[1]
- About 50% of all germ cell tumours are seminomas, or seminomatous germ cell tumours. They grow slower than non-seminomas.
Microscopic Pathology
Germ cell Tumors[2]
- Seminoma
- Clonal proliferation of neoplastic germ cells
- Fried-egg appearance
- Non-seminomas
- Embryonal carcinoma[3]
- Marked nuclear atypia
- Yolk sac tumor[2]
- Blander cytomorphology
- Hyaline-type globules
- Schiller-Duval bodies
- Choriocarcinoma
- Both syncytiotrophoblasts and cytotrophoblast cells
References
- ↑ Testicular cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=ab Accessed on October, 13 2015
- ↑ 2.0 2.1 Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H; et al. (1984). "Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases". Acta Radiol Oncol. 23 (4): 239–47. PMID 6093440.
- ↑ Talerman A, Haije WG, Baggerman L (1980). "Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP". Cancer. 46 (2): 380–5. PMID 6155988.