Testicular cancer pathophysiology: Difference between revisions
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On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked nuclear atypia is the characteristic finding of [[embryonal carcinoma]]; blander cytomorphology, hyaline-type globules, and Schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]]; syncytiotrophoblasts and cytotrophoblast cells are the characteristic findings of [[choriocarcinoma]]. | On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked nuclear atypia is the characteristic finding of [[embryonal carcinoma]]; blander cytomorphology, hyaline-type globules, and Schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]]; syncytiotrophoblasts and cytotrophoblast cells are the characteristic findings of [[choriocarcinoma]]. | ||
== | ==Pathogenesis== | ||
* More than 90% of all testicular cancers are [[germ cell tumors]]. This type of cancer starts in germ cells, which are the cells that make [[sperm]].<ref>Testicular cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=ab Accessed on October, 13 2015 </ref> | * More than 90% of all testicular cancers are [[germ cell tumors]]. This type of cancer starts in germ cells, which are the cells that make [[sperm]].<ref>Testicular cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=ab Accessed on October, 13 2015 </ref> | ||
* About 50% of all germ cell tumours are seminomas, or seminomatous germ cell tumours. They grow slower than non-seminomas. | * About 50% of all germ cell tumours are seminomas, or seminomatous germ cell tumours. They grow slower than non-seminomas. | ||
Revision as of 17:46, 19 October 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of seminoma; marked nuclear atypia is the characteristic finding of embryonal carcinoma; blander cytomorphology, hyaline-type globules, and Schiller-Duval bodies are characteristic findings of yolk sac tumor ; syncytiotrophoblasts and cytotrophoblast cells are the characteristic findings of choriocarcinoma.
Pathogenesis
- More than 90% of all testicular cancers are germ cell tumors. This type of cancer starts in germ cells, which are the cells that make sperm.[1]
- About 50% of all germ cell tumours are seminomas, or seminomatous germ cell tumours. They grow slower than non-seminomas.
Microscopic Pathology
Germ cell Tumors[2]
- Clonal proliferation of neoplastic germ cells
- Fried-egg appearance
- Non-seminomas
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- Marked nuclear atypia
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- Blander cytomorphology
- Hyaline-type globules
- Schiller-Duval bodies
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- Both syncytiotrophoblasts and cytotrophoblast cells
References
- ↑ Testicular cancer. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/testicular-cancer/cancerous-tumours/?region=ab Accessed on October, 13 2015
- ↑ 2.0 2.1 Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H; et al. (1984). "Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases". Acta Radiol Oncol. 23 (4): 239–47. PMID 6093440.
- ↑ Talerman A, Haije WG, Baggerman L (1980). "Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP". Cancer. 46 (2): 380–5. PMID 6155988.