Uveal melanoma epidemiology and demographics: Difference between revisions
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==Overview== | ==Overview== | ||
The incidence of uveal melanoma in the United States is approximately .43 per 100,000 individuals. The majority of uveal melanoma cases are reported in Europe and United States. The incidence of uveal melanoma increases with age; the median age at diagnosis is 60 years. Males are more commonly affected with uveal melanoma than females. | The incidence of uveal melanoma in the United States is approximately 0.43 per 100,000 individuals. The majority of uveal melanoma cases are reported in Europe and United States. The incidence of uveal melanoma increases with age; the median age at diagnosis is 60 years. Males are more commonly affected with uveal melanoma than females. | ||
Uveal melanoma commonly affects individuals older than twenty years of age. Caucasians are more commonly affected with uveal melanoma than Africans.<ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref><ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref> | Uveal melanoma commonly affects individuals older than twenty years of age. Caucasians are more commonly affected with uveal melanoma than Africans.<ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref><ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
Uveal melanoma comprises approximately 5–12% of all melanomas. The choroid posterior to the equator, often referred to as the posterior choroid, is the most common site involved with nearly 85% of cases localized to this region. Anterior uveal melanoma involves the ciliary body, iris, and/or choroid anterior to the equator and comprises 9-15% of uveal melanomas.<ref name="pmid22466491">{{cite journal| author=Shields CL, Kaliki S, Furuta M, Mashayekhi A, Shields JA| title=Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases. | journal=Retina | year= 2012 | volume= 32 | issue= 7 | pages= 1363-72 | pmid=22466491 | doi=10.1097/IAE.0b013e31824d09a8 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22466491 }} </ref> Melanoma localized to the iris and the ciliary body encompasses approximately 2-4% and 4-7% of uveal melanoma cases respectively.<ref name="pmid22370659 [">{{cite journal| author=Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA| title=Iris melanoma: features and prognosis in 317 children and adults. | journal=J AAPOS | year= 2012 | volume= 16 | issue= 1 | pages= 10-6 | pmid=22370659 [ | doi=10.1016/j.jaapos.2011.10.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22370659 }} </ref> The incidence of uveal melanoma in Europe and United States is comparable to that in New zealand and Australia. In Europe, a lower incidence is reported in the south of Italy and Spain, about 2 per million, whereas registries in France, the Netherlands, Germany and Switzerland has values around 4 to 5 per million. The United Kingdom registered over 6 per million cases of uveal melanoma, and the highest incidence is up to > 8 per million in Denmark and Norway. Uveal melanoma is less common in Asians.<ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref> Approximately 2% of uveal melanomas are found in patients younger than 20 year of age. | Uveal melanoma comprises approximately 5–12% of all melanomas. The choroid posterior to the equator, often referred to as the [[posterior choroid]], is the most common site involved with nearly 85% of cases localized to this region. Anterior uveal melanoma involves the [[ciliary body]], [[iris]], and/or [[choroid]] anterior to the equator and comprises 9-15% of uveal melanomas.<ref name="pmid22466491">{{cite journal| author=Shields CL, Kaliki S, Furuta M, Mashayekhi A, Shields JA| title=Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases. | journal=Retina | year= 2012 | volume= 32 | issue= 7 | pages= 1363-72 | pmid=22466491 | doi=10.1097/IAE.0b013e31824d09a8 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22466491 }} </ref> Melanoma localized to the iris and the ciliary body encompasses approximately 2-4% and 4-7% of uveal melanoma cases respectively.<ref name="pmid22370659 [">{{cite journal| author=Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA| title=Iris melanoma: features and prognosis in 317 children and adults. | journal=J AAPOS | year= 2012 | volume= 16 | issue= 1 | pages= 10-6 | pmid=22370659 [ | doi=10.1016/j.jaapos.2011.10.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22370659 }} </ref> The incidence of uveal melanoma in Europe and United States is comparable to that in New zealand and Australia. In Europe, a lower incidence is reported in the south of Italy and Spain, about 2 per million, whereas registries in France, the Netherlands, Germany and Switzerland has values around 4 to 5 per million. The United Kingdom registered over 6 per million cases of uveal melanoma, and the highest incidence is up to > 8 per million in Denmark and Norway. Uveal melanoma is less common in Asians.<ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref> Approximately 2% of uveal melanomas are found in patients younger than 20 year of age. | ||
===Incidence=== | ===Incidence=== | ||
The incidence of uveal melanoma in the United States is approximately .43 per 100, 000 individuals. The incidence of uveal melanoma is approximately .53 to 1.09 cases per 100, 000 individuals worldwide. Males have a higher incidence than females. The incidence of uveal melanoma in males and females is approximately .49 and .37 per 100,000 individuals respectively. The incidence of uveal melanoma is approximately 1200–1500 new cases per year in the USA.<ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref> | The incidence of uveal melanoma in the United States is approximately 0.43 per 100, 000 individuals. The incidence of uveal melanoma is approximately .53 to 1.09 cases per 100, 000 individuals worldwide. Males have a higher incidence than females. The incidence of uveal melanoma in males and females is approximately 0.49 and 0.37 per 100,000 individuals respectively. The incidence of uveal melanoma is approximately 1200–1500 new cases per year in the USA.<ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref> | ||
===Prevalance=== | ===Prevalance=== | ||
===Age=== | ===Age=== | ||
Uveal melanoma is diagnosed mostly at older ages, with a progressively rising, age-specific, incidence rate that peaks near the age of 70 years. Approximately 80% of the primary intraocular tumors are diagnosed as uveal melanoma in patients above the age of 20 years, and with a mean age of diagnosis of 60 years.<ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref> | Uveal melanoma is diagnosed mostly at older ages, with a progressively rising, age-specific, incidence rate that peaks near the age of 70 years. Approximately 80% of the primary intraocular [[tumors]] are diagnosed as uveal melanoma in patients above the age of 20 years, and with a mean age of diagnosis of 60 years.<ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref> | ||
===Gender=== | ===Gender=== | ||
Males are more commonly affected with uveal melanoma than females. | Males are more commonly affected with uveal melanoma than females. | ||
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== References == | == References == | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
The incidence of uveal melanoma in the United States is approximately 0.43 per 100,000 individuals. The majority of uveal melanoma cases are reported in Europe and United States. The incidence of uveal melanoma increases with age; the median age at diagnosis is 60 years. Males are more commonly affected with uveal melanoma than females. Uveal melanoma commonly affects individuals older than twenty years of age. Caucasians are more commonly affected with uveal melanoma than Africans.[1][2]
Epidemiology and Demographics
Uveal melanoma comprises approximately 5–12% of all melanomas. The choroid posterior to the equator, often referred to as the posterior choroid, is the most common site involved with nearly 85% of cases localized to this region. Anterior uveal melanoma involves the ciliary body, iris, and/or choroid anterior to the equator and comprises 9-15% of uveal melanomas.[3] Melanoma localized to the iris and the ciliary body encompasses approximately 2-4% and 4-7% of uveal melanoma cases respectively.[4] The incidence of uveal melanoma in Europe and United States is comparable to that in New zealand and Australia. In Europe, a lower incidence is reported in the south of Italy and Spain, about 2 per million, whereas registries in France, the Netherlands, Germany and Switzerland has values around 4 to 5 per million. The United Kingdom registered over 6 per million cases of uveal melanoma, and the highest incidence is up to > 8 per million in Denmark and Norway. Uveal melanoma is less common in Asians.[1] Approximately 2% of uveal melanomas are found in patients younger than 20 year of age.
Incidence
The incidence of uveal melanoma in the United States is approximately 0.43 per 100, 000 individuals. The incidence of uveal melanoma is approximately .53 to 1.09 cases per 100, 000 individuals worldwide. Males have a higher incidence than females. The incidence of uveal melanoma in males and females is approximately 0.49 and 0.37 per 100,000 individuals respectively. The incidence of uveal melanoma is approximately 1200–1500 new cases per year in the USA.[2]
Prevalance
Age
Uveal melanoma is diagnosed mostly at older ages, with a progressively rising, age-specific, incidence rate that peaks near the age of 70 years. Approximately 80% of the primary intraocular tumors are diagnosed as uveal melanoma in patients above the age of 20 years, and with a mean age of diagnosis of 60 years.[1]
Gender
Males are more commonly affected with uveal melanoma than females.
Race
Caucasians are approximately 150 times more frequently affected with uveal melanoma than Africans.[1]
References
- ↑ 1.0 1.1 1.2 1.3 van, J.G.M.; Koopmans, A.E.; Verdijk, R.M.; Naus, N.C.; de, A.; Kilic, E. (2013). "Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma". doi:10.5772/53631.
- ↑ 2.0 2.1 Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015
- ↑ Shields CL, Kaliki S, Furuta M, Mashayekhi A, Shields JA (2012). "Clinical spectrum and prognosis of uveal melanoma based on age at presentation in 8,033 cases". Retina. 32 (7): 1363–72. doi:10.1097/IAE.0b013e31824d09a8. PMID 22466491.
- ↑ Shields CL, Kaliki S, Shah SU, Luo W, Furuta M, Shields JA (2012). "Iris melanoma: features and prognosis in 317 children and adults". J AAPOS. 16 (1): 10–6. doi:10.1016/j.jaapos.2011.10.012. PMID [ 22370659 [ Check
|pmid=value (help).