Hairy cell leukemia natural history: Difference between revisions
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==Prognosis== | ==Prognosis== | ||
* Prognosis is generally poor, and the 5-year survival rate of patients with chronic lymphocytic leukemia is approximately 90%.<ref name=" | * Prognosis is generally poor, and the 5-year survival rate of patients with chronic lymphocytic leukemia is approximately 90%.<ref name="gov">Hairy cell leukemia. National Cancer Institute (2015) http://www.cancer.gov/types/leukemia/hp/hairy-cell-treatment-pdq Accessed on October, 28 2015</ref><ref name="uk">Statistics and outlook for hairy cell leukaemia. CANCER RESEARCH UK (2015) http://www.cancerresearchuk.org/about-cancer/type/hairy-cell-leukaemia/treatment/statistics-and-outlook-for-hairy-cell-leukaemia Accessed on October, 28 2015</ref> | ||
* Poor prognostic factors for hairy lymphocytic leukemia patients include old age, female gender, and African American race.<ref>{{Cite journal| author = [[Rekha Chandran]], [[Stuart K. Gardiner]], [[Stephen D. Smith]] & [[Stephen E. Spurgeon]]| title = Improved survival in hairy cell leukaemia over three decades: a SEER database analysis of prognostic factors| journal = [[British journal of haematology]]| volume = 163| issue = 3| pages = 407–409| year = 2013| month = November| doi = 10.1111/bjh.12490| pmid = 23889044}}</ref> | * Poor prognostic factors for hairy lymphocytic leukemia patients include old age, female gender, and African American race.<ref>{{Cite journal| author = [[Rekha Chandran]], [[Stuart K. Gardiner]], [[Stephen D. Smith]] & [[Stephen E. Spurgeon]]| title = Improved survival in hairy cell leukaemia over three decades: a SEER database analysis of prognostic factors| journal = [[British journal of haematology]]| volume = 163| issue = 3| pages = 407–409| year = 2013| month = November| doi = 10.1111/bjh.12490| pmid = 23889044}}</ref> | ||
* The table below lists prognostic factors for hairy lymphocytic leukemia patients:<ref>{{cite journal |vauthors=Stewart DJ, Smith TL, Keating MJ, McCredie KB, Hersh EM, Quesada J, Freireich EJ |title=Prognostic factors in hairy cell leukemia (leukemic reticuloendotheliosis) |journal=Cancer |volume=53 |issue=5 |pages=1198–1201 |year=1984 |pmid=6692307 |doi= |url=}}</ref> | * The table below lists prognostic factors for hairy lymphocytic leukemia patients:<ref>{{cite journal |vauthors=Stewart DJ, Smith TL, Keating MJ, McCredie KB, Hersh EM, Quesada J, Freireich EJ |title=Prognostic factors in hairy cell leukemia (leukemic reticuloendotheliosis) |journal=Cancer |volume=53 |issue=5 |pages=1198–1201 |year=1984 |pmid=6692307 |doi= |url=}}</ref> | ||
Revision as of 19:23, 28 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Most patients with hairy cell leukemia are asymptomatic at time of diagnosis. If left untreated, most of the patients with hairy cell leukemia will gradually develop anemia, recurrent infections, and recurrent bleeds. Common complications of hairy cell leukemia are mainly due to bone marrow failure.
Natural History
- Most patients with hairy cell leukemia are asymptomatic at time of diagnosis. If left untreated, most of the patients with hairy cell leukemia will gradually develop anemia, recurrent infections, and recurrent bleeding.[1][2][3]
Complications
- Anemia
- Recurrent infections
- Major recurrent bleeding
- Splenic rupture
Prognosis
- Prognosis is generally poor, and the 5-year survival rate of patients with chronic lymphocytic leukemia is approximately 90%.[2][4]
- Poor prognostic factors for hairy lymphocytic leukemia patients include old age, female gender, and African American race.[5]
- The table below lists prognostic factors for hairy lymphocytic leukemia patients:[6]
| Prognostic Factor | Description |
|---|---|
| Age |
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| Gender |
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| Race |
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| Infections |
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| Hepatomegaly |
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| Hemoglobin concentration |
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| Reticulocyte count |
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| Neutrophil count |
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| Alkaline phosphatase |
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References
- ↑ 1.0 1.1 Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Signs_and_symptoms Accessed on October, 28 2015
- ↑ 2.0 2.1 2.2 Hairy cell leukemia. National Cancer Institute (2015) http://www.cancer.gov/types/leukemia/hp/hairy-cell-treatment-pdq Accessed on October, 28 2015
- ↑ 3.0 3.1 What is Hairy Cell Leukemia? Hairy Cell Leukemia Foundation (2015) https://www.hairycellleukemia.org/about-hcl/what-is-hairy-cell-leukemia/ Accessed on October, 19 2015
- ↑ Statistics and outlook for hairy cell leukaemia. CANCER RESEARCH UK (2015) http://www.cancerresearchuk.org/about-cancer/type/hairy-cell-leukaemia/treatment/statistics-and-outlook-for-hairy-cell-leukaemia Accessed on October, 28 2015
- ↑ Rekha Chandran, Stuart K. Gardiner, Stephen D. Smith & Stephen E. Spurgeon (2013). "Improved survival in hairy cell leukaemia over three decades: a SEER database analysis of prognostic factors". British journal of haematology. 163 (3): 407–409. doi:10.1111/bjh.12490. PMID 23889044. Unknown parameter
|month=ignored (help) - ↑ Stewart DJ, Smith TL, Keating MJ, McCredie KB, Hersh EM, Quesada J, Freireich EJ (1984). "Prognostic factors in hairy cell leukemia (leukemic reticuloendotheliosis)". Cancer. 53 (5): 1198–1201. PMID 6692307.