Hairy cell leukemia classification: Difference between revisions
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* '''The male to female ratio is approximately 4 to 1'''<br> | * '''The male to female ratio is approximately 4 to 1'''<br> | ||
* '''The median age at diagnosis is 55 years'''<br> | * '''The median age at diagnosis is 55 years'''<br> | ||
* '''Less than 10% lymphocytosis is observed'''<br> | * '''Less than 10% [[lymphocytosis]] is observed'''<br> | ||
* '''Decreased level of monocyte on peripheral blood smear'''<br> | * '''Decreased level of [[monocyte]] on peripheral blood smear'''<br> | ||
* '''Decreased hemoglobin level in approximately 85% of the patients'''<br> | * '''Decreased [[hemoglobin]] level in approximately 85% of the patients'''<br> | ||
* '''Thrombocytopenia is present in approximately 80% of the patients'''<br> | * '''[[Thrombocytopenia]] is present in approximately 80% of the patients'''<br> | ||
* '''CD103+, CD11c+, and CD25+ on immunophenotype'''<br> | * '''[[CD103]] +ve, [[CD11c]] +ve, and [[CD25]] +ve on immunophenotype'''<br> | ||
* '''DBA | * '''[[DBA 44]] +ve, [[Cyclin D1]] +ve, and [[Annexin A1]] +ve on immunohistochemistry'''<br> | ||
* '''Presence of BRAF V600E mutation on cytogenetic tests''' | * '''Presence of [[BRAF]] V600E mutation on cytogenetic tests''' | ||
</div>|A03=<div style="width: 20em; padding:0.5em;text-align:left"> | </div>|A03=<div style="width: 20em; padding:0.5em;text-align:left"> | ||
* '''Occurs in approximately 5% of the cases'''<br> | * '''Occurs in approximately 5% of the cases'''<br> | ||
* '''The male to female ratio is approximately 2 to 1'''<br> | * '''The male to female ratio is approximately 2 to 1'''<br> | ||
* '''The median age at diagnosis is greater than 70 years'''<br> | * '''The median age at diagnosis is greater than 70 years'''<br> | ||
* '''Greater than 90% lymphocytosis is observed'''<br> | * '''Greater than 90% [[lymphocytosis]] is observed'''<br> | ||
* '''Normal level of monocyte on peripheral blood smear'''<br> | * '''Normal level of [[monocyte]] on peripheral blood smear'''<br> | ||
* '''Normal hemoglobin level in most of the patients'''<br> | * '''Normal [[hemoglobin]] level in most of the patients'''<br> | ||
* '''Normal platelets count in most of the patients'''<br> | * '''Normal [[platelets]] count in most of the patients'''<br> | ||
* '''CD103+, CD11c+, and CD25- on immunophenotype'''<br> | * '''[[CD103]] +ve, [[CD11c]] +ve, and [[CD25]] -ve on immunophenotype'''<br> | ||
* '''DBA | * '''[[DBA 44]] +ve, [[Cyclin D1]] +ve, and [[Annexin A1]] -ve on immunohistochemistry'''<br> | ||
* '''Presence of BRAF wild type mutation on cytogenetic tests'''</div>}} | * '''Presence of [[BRAF]] wild type mutation on cytogenetic tests'''</div>}} | ||
{{familytree/end}} | {{familytree/end}} | ||
<br> | <br> | ||
Revision as of 18:55, 30 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
- Hairy cell leukemia may be classified into two subtypes which include hairy cell leukemia (classic) and hairy cell leukemia variant.[1]
Classification
- Hairy cell leukemia may be classified into two subtypes which include:[1]
- Hairy cell leukemia (classic)
- Hairy cell leukemia variant
- Hairy cell leukemia variant is still considered a provisional entity at this time, as the WHO is unable to recognize it as distinct diseases due to insufficient evidence.[2]
- The chart below illustrates characteristic findings associated with each subtype:[3][4]
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Hairy cell leukemia | Hairy cell leukemia variant | ||||||||||||||||||||||||||||||||||
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References
- ↑ 1.0 1.1 Hairy cell leukemia. Wikipedia (2015) https://en.wikipedia.org/wiki/Hairy_cell_leukemia#Classification Accessed on October, 17 2015
- ↑ Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES (2011). "The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications". Blood. 117 (19): 5019–32. doi:10.1182/blood-2011-01-293050. PMC 3109529. PMID 21300984.
- ↑ Matutes E (2006). "Immunophenotyping and differential diagnosis of hairy cell leukemia". Hematol Oncol Clin North Am. 20 (5): 1051–63. doi:10.1016/j.hoc.2006.06.012. PMID 16990106.
- ↑ Hairy-Cell Leukemia. Onkopedia (2015) https://www.onkopedia-guidelines.info/en/onkopedia/guidelines/hairy-cell-leukemia/@@view/html/index.html#5 Accessed on October, 16 2015