Subependymal giant cell astrocytoma pathophysiology: Difference between revisions
No edit summary |
|||
| Line 13: | Line 13: | ||
===Associated Conditions=== | ===Associated Conditions=== | ||
Subependymal giant cell | Subependymal giant cell astrocytomas are characteristic brain tumors that occur in 10% to 20% of [[tuberous sclerosis complex]] patients and are almost exclusively associated with tuberous sclerosis complex.<ref name="RothRoach2013">{{cite journal|last1=Roth|first1=Jonathan|last2=Roach|first2=E. Steve|last3=Bartels|first3=Ute|last4=Jóźwiak|first4=Sergiusz|last5=Koenig|first5=Mary Kay|last6=Weiner|first6=Howard L.|last7=Franz|first7=David N.|last8=Wang|first8=Henry Z.|title=Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012|journal=Pediatric Neurology|volume=49|issue=6|year=2013|pages=439–444|issn=08878994|doi=10.1016/j.pediatrneurol.2013.08.017}}</ref> | ||
===Gross Pathology=== | ===Gross Pathology=== | ||
Revision as of 21:10, 2 November 2015
|
Subependymal giant cell astrocytoma Microchapters |
|
Differentiating Subependymal Giant Cell Astrocytoma from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Subependymal giant cell astrocytoma pathophysiology On the Web |
|
American Roentgen Ray Society Images of Subependymal giant cell astrocytoma pathophysiology |
|
Subependymal giant cell astrocytoma pathophysiology in the news |
|
Blogs on Subependymal giant cell astrocytoma pathophysiology |
|
Risk calculators and risk factors for Subependymal giant cell astrocytoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Genetic
- Development of subependymal giant cell astrocytoma is the result of multiple genetic mutations.
- Genes involved in the pathogenesis of subependymal giant cell astrocytoma include:
Associated Conditions
Subependymal giant cell astrocytomas are characteristic brain tumors that occur in 10% to 20% of tuberous sclerosis complex patients and are almost exclusively associated with tuberous sclerosis complex.[1]
Gross Pathology
- On gross pathology, subependymal giant cell astrocytoma is characterized by:
- Common intracranial sites associated with subependymal giant cell astrocytoma include:
| Anatomical Location | Summary |
|---|---|
 |
Microscopic pathology
On microscopic histopathological analysis, subependymal giant cell astrocytoma is characterized by:
According to the WHO classification of tumors of the central nervous system, subependymal giant cell astrocytoma is classified into a WHO grade I tumor.
Immunohistochemistry
Subependymal giant cell astrocytoma is demonstrated by positivity to tumor markers such as:
Reference
- ↑ Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.
- ↑ "Non-random aneuploidy specifies subgroups of pilocytic astrocytoma and correlates with older age". Oncotarget. 2015. doi:10.18632/oncotarget.5571. ISSN 1949-2553.