Hepatoblastoma pathophysiology: Difference between revisions
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==Immunohistochemistry== | |||
*Alpha fetoprotein positive | |||
*Hepatocyte specific antigen positive especially in fetal component | |||
*''Beta-catenin'' positive (cytoplasmic and nuclear) | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 18:07, 4 November 2015
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Hepatoblastoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatoblastoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Hepatoblastoma pathophysiology |
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Risk calculators and risk factors for Hepatoblastoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nawal Muazam M.D.[2]
Overview
Pathophysiology
Genetics
Genes involved in the pathogenesis of hepatoblastoma include:[1]
Gross Pathology
On gross pathology, well circumscribed large masses, usually single, with heterogeneous cut surface are findings of hepatoblastoma.[2]
Microscopic Pathology
On microscopic histopathological analysis, hepatoblastoma is characterized by:[3]
- Small round cell tumor
- Fetal hepatocytes ~ 1:3 NC ratio, eosinophilic cytoplasm
- +/- Mesenchymal component
- Immature fibrous tissue, osteoid or cartilage
-
![Micrograph of a hepatoblastoma, a type of liver cancer found in infants and young children. H&E stain.[4]](/images/0/09/Hepatoblastoma_microscopy1.jpg)
Micrograph of a hepatoblastoma, a type of liver cancer found in infants and young children. H&E stain.[4]
![Micrograph of a hepatoblastoma, a type of liver cancer found in infants and young children. H&E stain.[4]](/index.php/File:Hepatoblastoma_microscopy1.jpg)
Immunohistochemistry
- Alpha fetoprotein positive
- Hepatocyte specific antigen positive especially in fetal component
- Beta-catenin positive (cytoplasmic and nuclear)
References
- ↑ Jia, Deshui; Dong, Rui; Jing, Ying; Xu, Dan; Wang, Qifeng; Chen, Lei; Li, Qigen; Huang, Yuping; Zhang, Yuannv; Zhang, Zhenfeng; Liu, Li; Zheng, Shan; Xia, Qiang; Wang, Hongyang; Dong, Kuiran; He, Xianghuo (2014). "Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex". Hepatology. 60 (5): 1686–1696. doi:10.1002/hep.27243. ISSN 0270-9139.
- ↑ Pathology of hepatoblastoma. Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/hepatoblastoma. Accessed on November 3, 2015
- ↑ Microscopic features of hepatoblastoma. Librepathology (2015). Accessed on http://librepathology.org/wiki/index.php/Liver_neoplasms#Hepatoblastoma. November 3, 2015
- ↑ Hepatoblastoma. Librepathology (2015). http://librepathology.org/wiki/index.php/File:Hepatoblastoma_-_2_-_very_high_mag.jpg Accessed on November 3, 2015
