Subependymal giant cell astrocytoma surgery: Difference between revisions
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==Gamma Knife Radiosurgery== | ==Gamma Knife Radiosurgery== | ||
*Gamma knife radiosurgery has been used to treat subependymal giant cell astrocytoma. | |||
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==Reference== | ==Reference== | ||
Revision as of 23:24, 5 November 2015
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Subependymal giant cell astrocytoma Microchapters |
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Differentiating Subependymal Giant Cell Astrocytoma from other Diseases |
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Subependymal giant cell astrocytoma surgery On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Surgery
- Surgery is the mainstay of treatment for subependymal giant cell astrocytoma.[1]
- Treatment of subependymal giant cell astrocytoma has been solely surgical because of a lack of responsiveness to other strategies such as chemotherapy or radiation. The latter may also be associated with an increased risk of secondary malignancies.[2]
- Generally, it is agreed that small tumors are usually less invasive and that resecting noninvasive small tumors, diagnosed while still asymptomatic, is associated with excellent clinical outcomes with low morbidity and mortality.
- However, when diagnosed at a later stage, the tumor more often affects and invades neighboring structures (fornix, hypothalamus, basal ganglia, and genu of internal capsule) and resection is associated with higher surgical morbidity and mortality.
- The choice of treatment in subependymal giant cell astrocytoma still is dependent on the experience of the individual physician. Despite the growing evidence on mTORi-induced tumor shrinkage, many centers still strictly advocate surgical treatment, whereas others prefer medical therapy.[2]
- Indications of surgery in subependymal giant cell astrocytoma include:[1]
- Acute hydrocephalus
- Worsened seizure burden
- Significant interval growth on serial neuroimaging
- Complications of surgery in subependymal giant cell astrocytoma include:[1]
Gamma Knife Radiosurgery
- Gamma knife radiosurgery has been used to treat subependymal giant cell astrocytoma.
Reference
- ↑ 1.0 1.1 1.2 Campen CJ, Porter BE (2011). "Subependymal Giant Cell Astrocytoma (SEGA) Treatment Update". Curr Treat Options Neurol. 13 (4): 380–5. doi:10.1007/s11940-011-0123-z. PMC 3130084. PMID 21465222.
- ↑ 2.0 2.1 Roth, Jonathan; Roach, E. Steve; Bartels, Ute; Jóźwiak, Sergiusz; Koenig, Mary Kay; Weiner, Howard L.; Franz, David N.; Wang, Henry Z. (2013). "Subependymal Giant Cell Astrocytoma: Diagnosis, Screening, and Treatment. Recommendations From the International Tuberous Sclerosis Complex Consensus Conference 2012". Pediatric Neurology. 49 (6): 439–444. doi:10.1016/j.pediatrneurol.2013.08.017. ISSN 0887-8994.