Pseudomyxoma peritonei causes: Difference between revisions
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*The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. | *The primary tumor appears to arise from the [[MUC2]] expressing [[goblet cell]]s and most commonly from these cells in the appendix. | ||
*The ''K-Ras'' and ''p53'' genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions. | *The ''K-Ras'' and ''p53'' genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions. | ||
*While the majority of | *While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas,<ref name=Young_2004>{{cite journal |author=Young R |title=Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms |journal=Semin Diagn Pathol |volume=21 |issue=2 |pages=134–50 |year=2004 |pmid=15807473 |doi=10.1053/j.semdp.2004.12.002}}</ref> other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several [[mucinous]] tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).<ref name=Jacquemin_2005>{{cite journal |author=Jacquemin G, Laloux P |title=Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases |journal=Acta Chir Belg |volume=105 |issue=2 |pages=127–33 |year=2005 |pmid=15906901}}</ref> | ||
== References == | == References == | ||
Revision as of 14:16, 15 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pseudomyxoma peritonei is caused by a pre-existing intraperitoneal mucinous neoplasm. The K-Ras and p53 genes may be involved in the oncogenesis.
Causes
- Since initial descriptions of pseudomyxoma peritonei as a syndrome in association with an ovarian tumor or an appendiceal mucocele, a pre-existing intraperitoneal mucinous neoplasm has been implicated as the primary cause of pseudomyxoma peritonei.
- Emerging evidence supports the appendiceal rather than ovarian origin of the disease.[1]
- The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix.
- The K-Ras and p53 genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions.
- While the majority of pseudomyxoma peritonei are associated with appendiceal carcinomas,[2] other conditions may also be found, including disseminated peritoneal adenomucinosis (DPAM), peritoneal carcinomas, or several mucinous tumors (mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma).[3]
References
- ↑ Amini, Afshin; Masoumi-Moghaddam, Samar; Ehteda, Anahid; Morris, David (2014). "Secreted mucins in pseudomyxoma peritonei: pathophysiological significance and potential therapeutic prospects". Orphanet Journal of Rare Diseases. 9 (1): 71. doi:10.1186/1750-1172-9-71. ISSN 1750-1172.
- ↑ Young R (2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Semin Diagn Pathol. 21 (2): 134–50. doi:10.1053/j.semdp.2004.12.002. PMID 15807473.
- ↑ Jacquemin G, Laloux P (2005). "Pseudomyxoma peritonei: review on a cluster of peritoneal mucinous diseases". Acta Chir Belg. 105 (2): 127–33. PMID 15906901.