Malignant peripheral nerve sheath tumor overview: Difference between revisions
Shanshan Cen (talk | contribs) No edit summary |
Shanshan Cen (talk | contribs) No edit summary |
||
| Line 12: | Line 12: | ||
On gross pathology, a large firm [[mass]] with [[necrosis]] and [[hemorrhage]] is the characteristic finding of malignant peripheral nerve sheath tumor. On microscopic histopathological analysis, [[spindle cells]], nuclear atypia, [[mitoses]], and herring bone pattern are characteristic findings of malignant peripheral nerve sheath tumor.<ref>Malignant peripheral nerve sheath tumor. Librepathology 2015. http://librepathology.org/wiki/index.php/Malignant_peripheral_nerve_sheath_tumour</ref> [[Neurofibromatosis type I]] (NF1) gene is involved in the pathogenesis of malignant peripheral nerve sheath tumor.<ref>{{cite journal|last=Ferrari|first=Andrea|author2=Gianni Bisogno |author3=Modesto Carli |title=Management Of Childhood Malignant Peripheral Nerve Sheath Tumor | journal=Pediatric Drugs | date=2007|volume=9|issue=4|pages=239–48|accessdate=5 Mar 2014 | pmid=17705563 | doi=10.2165/00148581-200709040-00005}}</ref> | On gross pathology, a large firm [[mass]] with [[necrosis]] and [[hemorrhage]] is the characteristic finding of malignant peripheral nerve sheath tumor. On microscopic histopathological analysis, [[spindle cells]], nuclear atypia, [[mitoses]], and herring bone pattern are characteristic findings of malignant peripheral nerve sheath tumor.<ref>Malignant peripheral nerve sheath tumor. Librepathology 2015. http://librepathology.org/wiki/index.php/Malignant_peripheral_nerve_sheath_tumour</ref> [[Neurofibromatosis type I]] (NF1) gene is involved in the pathogenesis of malignant peripheral nerve sheath tumor.<ref>{{cite journal|last=Ferrari|first=Andrea|author2=Gianni Bisogno |author3=Modesto Carli |title=Management Of Childhood Malignant Peripheral Nerve Sheath Tumor | journal=Pediatric Drugs | date=2007|volume=9|issue=4|pages=239–48|accessdate=5 Mar 2014 | pmid=17705563 | doi=10.2165/00148581-200709040-00005}}</ref> | ||
==Causes== | |||
Malignant peripheral nerve sheath tumor may be caused by a mutation on [[neurofibromatosis type I]] gene.<ref>{{cite book | last = Albright | first = A | title = Principles and practice of pediatric neurosurgery | publisher = Thieme | location = New York | year = 2008 | isbn = 1588903958 }}</ref><ref>{{cite journal|last=Ferrari|first=Andrea|author2=Gianni Bisogno |author3=Modesto Carli |title=Management Of Childhood Malignant Peripheral Nerve Sheath Tumor | journal=Pediatric Drugs | date=2007|volume=9|issue=4|pages=239–48|accessdate=5 Mar 2014 | pmid=17705563 | doi=10.2165/00148581-200709040-00005}}</ref> | |||
==References== | ==References== | ||
Revision as of 16:14, 7 December 2015
|
Malignant peripheral nerve sheath tumor Microchapters |
|
Differentiating Malignant Peripheral Nerve Sheath Tumor from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Malignant peripheral nerve sheath tumor overview On the Web |
|
American Roentgen Ray Society Images of Malignant peripheral nerve sheath tumor overview |
|
Malignant peripheral nerve sheath tumor overview in the news |
|
Directions to Hospitals Treating Malignant peripheral nerve sheath tumor |
|
Risk calculators and risk factors for Malignant peripheral nerve sheath tumor overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Malignant peripheral nerve sheath tumor (MPNST) is a form of cancer of the connective tissue surrounding nerves.
Classification
There is no classification system established for malignant peripheral nerve sheath tumor.
Pathophysiology
On gross pathology, a large firm mass with necrosis and hemorrhage is the characteristic finding of malignant peripheral nerve sheath tumor. On microscopic histopathological analysis, spindle cells, nuclear atypia, mitoses, and herring bone pattern are characteristic findings of malignant peripheral nerve sheath tumor.[1] Neurofibromatosis type I (NF1) gene is involved in the pathogenesis of malignant peripheral nerve sheath tumor.[2]
Causes
Malignant peripheral nerve sheath tumor may be caused by a mutation on neurofibromatosis type I gene.[3][4]
References
- ↑ Malignant peripheral nerve sheath tumor. Librepathology 2015. http://librepathology.org/wiki/index.php/Malignant_peripheral_nerve_sheath_tumour
- ↑ Ferrari, Andrea; Gianni Bisogno; Modesto Carli (2007). "Management Of Childhood Malignant Peripheral Nerve Sheath Tumor". Pediatric Drugs. 9 (4): 239–48. doi:10.2165/00148581-200709040-00005. PMID 17705563.
|access-date=requires|url=(help) - ↑ Albright, A (2008). Principles and practice of pediatric neurosurgery. New York: Thieme. ISBN 1588903958.
- ↑ Ferrari, Andrea; Gianni Bisogno; Modesto Carli (2007). "Management Of Childhood Malignant Peripheral Nerve Sheath Tumor". Pediatric Drugs. 9 (4): 239–48. doi:10.2165/00148581-200709040-00005. PMID 17705563.
|access-date=requires|url=(help)