Atypical teratoid rhabdoid tumor diagnostic criteria: Difference between revisions
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==Diagnostic Criteria== | ==Diagnostic Criteria== | ||
The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the CNS criteria, which include: | The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the CNS criteria, which include:<ref name="SlavcChocholous2014">{{cite journal|last1=Slavc|first1=Irene|last2=Chocholous|first2=Monika|last3=Leiss|first3=Ulrike|last4=Haberler|first4=Christine|last5=Peyrl|first5=Andreas|last6=Azizi|first6=Amedeo A.|last7=Dieckmann|first7=Karin|last8=Woehrer|first8=Adelheid|last9=Peters|first9=Christina|last10=Widhalm|first10=Georg|last11=Dorfer|first11=Christian|last12=Czech|first12=Thomas|title=Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992-2012|journal=Cancer Medicine|volume=3|issue=1|year=2014|pages=91–100|issn=20457634|doi=10.1002/cam4.161}}</ref> | ||
*Presence of rhabdoid tumor cells and/or divergent differentiation along [[epithelial]], [[mesenchymal]], [[neuronal]], or [[glial|glial lines]] | *Presence of rhabdoid tumor cells and/or divergent differentiation along [[epithelial]], [[mesenchymal]], [[neuronal]], or [[glial|glial lines]] | ||
:{{and}} | :{{and}} | ||
Revision as of 20:00, 14 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Diagnostic Criteria
The diagnosis of atypical teratoid rhabdoid tumor is based on the current WHO classification of tumors of the CNS criteria, which include:[1]
- Presence of rhabdoid tumor cells and/or divergent differentiation along epithelial, mesenchymal, neuronal, or glial lines
- AND
- Complete loss of SMARCB1 protein expression in tumor cell nuclei, but expression retained in preexisting cells (e.g., endothelial cells)
References
- ↑ Slavc, Irene; Chocholous, Monika; Leiss, Ulrike; Haberler, Christine; Peyrl, Andreas; Azizi, Amedeo A.; Dieckmann, Karin; Woehrer, Adelheid; Peters, Christina; Widhalm, Georg; Dorfer, Christian; Czech, Thomas (2014). "Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal therapy and delayed radiotherapy. The Medical University of Vienna Experience 1992-2012". Cancer Medicine. 3 (1): 91–100. doi:10.1002/cam4.161. ISSN 2045-7634.