Atypical teratoid rhabdoid tumor surgery: Difference between revisions
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==Overview== | ==Overview== | ||
==Surgery== | ==Surgery== | ||
*[[Surgery]] is the mainstay of treatment for atypical teratoid rhabdoid tumor.<ref name="GinnGajjar2012">{{cite journal|last1=Ginn|first1=Kevin F.|last2=Gajjar|first2=Amar|title=Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions|journal=Frontiers in Oncology|volume=2|year=2012|issn=2234-943X|doi=10.3389/fonc.2012.00114}}</ref> | *[[Surgery]] is the mainstay of treatment for atypical teratoid rhabdoid tumor.<ref name="GinnGajjar2012">{{cite journal|last1=Ginn|first1=Kevin F.|last2=Gajjar|first2=Amar|title=Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions|journal=Frontiers in Oncology|volume=2|year=2012|issn=2234-943X|doi=10.3389/fonc.2012.00114}}</ref> | ||
*Surgery plays a critical role in obtaining [[Tissue (biology)|tissue]] to make an accurate [[diagnosis]]. Surgery alone is not curative. | *Surgery plays a critical role in obtaining [[Tissue (biology)|tissue]] to make an accurate [[diagnosis]]. Surgery alone is not curative. | ||
*In addition, 30% of the atypical teratoid rhabdoid tumors are located supratentorially and there is a predilection for the cerebello-pontine angle, which makes surgical resection difficult. One-third or more children will have [[disseminated disease]] at the time of diagnosis. Total or near-total resections are often not possible.<ref>[http://www.utmb.edu/otoref/Grnds/Mass-CPA-040602/Mass-CPA-slides-040602.pdf PDF</ref> | *In addition, 30% of the atypical teratoid rhabdoid tumors are located supratentorially and there is a predilection for the cerebello-pontine angle, which makes surgical resection difficult. One-third or more children will have [[disseminated disease]] at the time of diagnosis. Total or near-total resections are often not possible.<ref name=asfdxgf>[http://www.utmb.edu/otoref/Grnds/Mass-CPA-040602/Mass-CPA-slides-040602.pdf PDF</ref> | ||
==Stem Cell Transplantation== | ==Stem Cell Transplantation== | ||
Revision as of 16:31, 21 December 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Surgery
- Surgery is the mainstay of treatment for atypical teratoid rhabdoid tumor.[1]
- Surgery plays a critical role in obtaining tissue to make an accurate diagnosis. Surgery alone is not curative.
- In addition, 30% of the atypical teratoid rhabdoid tumors are located supratentorially and there is a predilection for the cerebello-pontine angle, which makes surgical resection difficult. One-third or more children will have disseminated disease at the time of diagnosis. Total or near-total resections are often not possible.[2]
Stem Cell Transplantation
- Stem cell transplantation is indicated in very aggressive atypical teratoid rhabdoid tumors, to receive high doses of chemotherapy.[3]
- Autologous stem cell rescue: Thee patient's own stem cells are collected, and then high-dose chemotherapy is infused. Now, autologous stem cell transplantation is performed to help them recover from the chemotherapy.[4]
References
- ↑ Ginn, Kevin F.; Gajjar, Amar (2012). "Atypical Teratoid Rhabdoid Tumor: Current Therapy and Future Directions". Frontiers in Oncology. 2. doi:10.3389/fonc.2012.00114. ISSN 2234-943X.
- ↑ [http://www.utmb.edu/otoref/Grnds/Mass-CPA-040602/Mass-CPA-slides-040602.pdf PDF
- ↑ Treatment and care options of atypical teratoid rhabdoid tumor. Dana-Farber and Boston Children hospital cancer and blood disorder center 2015. http://www.danafarberbostonchildrens.org/conditions/brain-tumor/atypical-teratoid-rhabdoid-tumor.aspx. Accessed on December 21, 2015
- ↑ What treatment options are available for kids with ATRT? Rishi Lulla, MD, MS. St. Baldrick’s Foundation 2015. http://www.stbaldricks.org/blog/post/types-of-childhood-cancer-atypical-teratoid-rhabdoid-tumor-atrt/. Accessed on December 21, 2015