Parathyroid cancer history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

The hallmark of parathyroid cancer is neck mass. A positive history of multiple endocrine neoplasia (MEN) type I, hyperparathyroidism and previous radiation therapy to the head or neck is suggestive of parathyroid cancer. The most common symptoms of parathyroid cancer include weightloss, muscle weakness, fractures, constipation, fatigue and bone pain.

History

• A personal history of genetic diseases that are risk factors for parathyroid cancer, such as:

• Multiple endocrine neoplasia (MEN) type I
• Hyperparathyroidism-jaw tumour (HPT-JT) syndrome

• Previous radiation therapy to the head or neck

Common Symptoms

• Bone pain
• Pathological fractures
• Palpable neck mass
• Fatigue
• Muscle weakness
• Weight loss
• Dehydration
• Nausea
• Constipation
• Frequent thrist
• Kidney stone
• Poor appetite
• Frequent urination
• Vomiting

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