Paget's disease of the breast biopsy: Difference between revisions
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==Biopsy== | ==Biopsy== | ||
*Biopsy is diagnostic of Paget's disease of the breast. | *Biopsy is diagnostic of Paget's disease of the breast. | ||
*Biopsy can be performed by shaving, punch or incisional techniques, the latter being the most appropriate one. | *Biopsy can be performed by shaving, punch or incisional techniques, the latter being the most appropriate one.<ref name="Lopes FilhoLopes2015">{{cite journal|last1=Lopes Filho|first1=Lauro Lourival|last2=Lopes|first2=Ione Maria Ribeiro Soares|last3=Lopes|first3=Lauro Rodolpho Soares|last4=Enokihara|first4=Milvia M. S. S.|last5=Michalany|first5=Alexandre Osores|last6=Matsunaga|first6=Nobuo|title=Mammary and extramammary Paget's disease|journal=Anais Brasileiros de Dermatologia|volume=90|issue=2|year=2015|pages=225–231|issn=1806-4841|doi=10.1590/abd1806-4841.20153189}}</ref> | ||
*It is essential that the sample contains part of the lactiferous duct and if the areola is affected, it also needs to be represented in the sample to confirm the diagnosis. | *It is essential that the sample contains part of the lactiferous duct and if the areola is affected, it also needs to be represented in the sample to confirm the diagnosis. | ||
*Often histological exams are inconclusive and more biopsies, or even surgical removal of the entire nipple may be required. | *Often histological exams are inconclusive and more biopsies, or even surgical removal of the entire nipple may be required. | ||
Revision as of 15:57, 18 January 2016
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Paget's disease of the breast Microchapters |
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Differentiating Paget's disease of the breast from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Paget's disease of the breast biopsy On the Web |
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American Roentgen Ray Society Images of Paget's disease of the breast biopsy |
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Directions to Hospitals Treating Paget's disease of the breast |
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Risk calculators and risk factors for Paget's disease of the breast biopsy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Biopsy is diagnostic of Paget's disease of the breast.
Biopsy
- Biopsy is diagnostic of Paget's disease of the breast.
- Biopsy can be performed by shaving, punch or incisional techniques, the latter being the most appropriate one.[1]
- It is essential that the sample contains part of the lactiferous duct and if the areola is affected, it also needs to be represented in the sample to confirm the diagnosis.
- Often histological exams are inconclusive and more biopsies, or even surgical removal of the entire nipple may be required.
- The main histological characteristic is the presence of Paget cells, which are arranged in solid groups.
- On occasion, they form glandular arrangements outlining the basal epidermis and exhibit migration to the granular layer, similarly to melanocytes.
To view histopathologic characteristic features of Paget's disease of the breast, click here.
References
- ↑ Lopes Filho, Lauro Lourival; Lopes, Ione Maria Ribeiro Soares; Lopes, Lauro Rodolpho Soares; Enokihara, Milvia M. S. S.; Michalany, Alexandre Osores; Matsunaga, Nobuo (2015). "Mammary and extramammary Paget's disease". Anais Brasileiros de Dermatologia. 90 (2): 225–231. doi:10.1590/abd1806-4841.20153189. ISSN 1806-4841.