Chancroid natural history, complications and prognosis: Difference between revisions

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::''H. ducreyi'' facilitates infection of HIV
::''H. ducreyi'' facilitates infection of HIV
::Presence of HIV may result in atypical manifestations of chancroid including: increased number of lesions, extragenital lesions, delayed treatment response<ref name="ChancroidUpToDate"></ref>
::Presence of HIV may result in atypical manifestations of chancroid including: increased number of lesions, extragenital lesions, delayed treatment response<ref name="ChancroidUpToDate"></ref>
*Coinfection with [[syphilis]]
*Coinfection with ''[[Treponema pallidum]]''
*Superinfection of lesions by other anaerobic bacteria such as [[Fusobacterium]] and [[Bacteriodes]]<ref name=cur>{{cite book|title=CURRENT Diagnosis & Treatment of Sexually Transmitted Diseases|year=2007|publisher=McGraw-Hill Companies,Inc.|isbn=9780071509619|pages=69–74}}</ref><ref name="ChancroidWikipedia">Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed January 15, 2016.</ref>
::[[Syphilis]] has been shown to commonly occur with chancroid<ref name="pmid26042815">{{cite journal| author=Workowski KA, Bolan GA, Centers for Disease Control and Prevention| title=Sexually transmitted diseases treatment guidelines, 2015. | journal=MMWR Recomm Rep | year= 2015 | volume= 64 | issue= RR-03 | pages= 1-137 | pmid=26042815 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26042815  }} </ref>
*Superinfection of lesions by other anaerobic bacteria such as [[Fusobacterium]] and [[Bacteroides]]<ref name=cur>{{cite book|title=CURRENT Diagnosis & Treatment of Sexually Transmitted Diseases|year=2007|publisher=McGraw-Hill Companies,Inc.|isbn=9780071509619|pages=69–74}}</ref><ref name="ChancroidWikipedia">Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed January 15, 2016.</ref>
*[[Phimosis]] in men<ref name="Lewis2003"></ref>
*[[Phimosis]] in men<ref name="Lewis2003"></ref>


Revision as of 19:00, 20 January 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.; Nate Michalak, B.A.; Serge Korjian M.D.

Overview

Natural History

  • The incubation period for H. ducreyi is typically 4 to 10 days, after which erythematous papules arise.[1]
  • Approximately 2 to 3 days after symptom onset, papules evolve into pustules.[2]
  • Pustules may resolve spontaneously or ulcerate in approximately 1-2 weeks since formation. Patients typically develop between 1-4 ulcers.
  • Inguinal lymphadenitis develops in approximately half of patients, usually unilaterally and more commonly in males than females, 1 to 2 weeks after appearance of primary ulcer.[3]
  • In approximately 25% of patients with lymphadenitis, lymph nodes may swell to form fluctuant buboes. Untreated buboes may rupture, discharge exudate, and ulcerate.[3]
  • Chancroid is not lethal.

Complications

H. ducreyi facilitates infection of HIV
Presence of HIV may result in atypical manifestations of chancroid including: increased number of lesions, extragenital lesions, delayed treatment response[1]
Syphilis has been shown to commonly occur with chancroid[4]

References

  1. ↑ 1.0 1.1 Chancroid. UpToDate (September 25, 2015). http://www.uptodate.com/contents/chancroid#H3 Accessed January 19, 2016.
  2. ↑ Spinola, S. M. (2002). "Immunopathogenesis of Haemophilus ducreyi Infection (Chancroid)". Infection and Immunity. 70 (4): 1667–1676. doi:10.1128/IAI.70.4.1667-1676.2002. ISSN 0019-9567.
  3. ↑ 3.0 3.1 3.2 Lewis, D A (2003). "Chancroid: clinical manifestations, diagnosis, and management". Sexually Transmitted Infections. 79 (1): 68–71. doi:10.1136/sti.79.1.68. ISSN 1368-4973.
  4. ↑ Workowski KA, Bolan GA, Centers for Disease Control and Prevention (2015). "Sexually transmitted diseases treatment guidelines, 2015". MMWR Recomm Rep. 64 (RR-03): 1–137. PMID 26042815.
  5. ↑ CURRENT Diagnosis & Treatment of Sexually Transmitted Diseases. McGraw-Hill Companies,Inc. 2007. pp. 69–74. ISBN 9780071509619.
  6. ↑ Chancroid. Wikipedia (July 16, 2015). https://en.wikipedia.org/wiki/Chancroid Accessed January 15, 2016.

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