Fibroma pathophysiology: Difference between revisions
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*No true hyaline cartilage formation is seen | *No true hyaline cartilage formation is seen | ||
*No mitotic activity is seen | *No mitotic activity is seen | ||
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File:120px-Bone ChondromyxoidFibroma HP2 PA (2).jpg|Histopathology specimen of a chondromyxoid fibroma showing stellate cells in myxoid stroma | File:120px-Bone ChondromyxoidFibroma HP2 PA (2).jpg|Histopathology specimen of a chondromyxoid fibroma showing stellate cells in myxoid stroma | ||
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File:853px-Bone ChondromyxoidFibroma MP2 PA.jpg|Histopathology specimen of a chondromyxoid fibroma showing Lobule with a darker (hypercellular) periphery and lighter (hypocellular) center. (SKB) | File:853px-Bone ChondromyxoidFibroma MP2 PA.jpg|Histopathology specimen of a chondromyxoid fibroma showing Lobule with a darker (hypercellular) periphery and lighter (hypocellular) center. (SKB) | ||
</gallery> | </gallery> | ||
==Ossifying Fibroma (Osteofibrous dysplasia)== | |||
===Gross Pathology=== | |||
On gross pathology, discrete mass that is well delineated from surrounding bone, tan-white, rubbery cut surface, firm to gritty and no encapsulation are characteristic findings of ossifying fibroma. | |||
===Microscopic Pathology=== | |||
Following features are noted on microscopic histopathological analysis of ossifying fibroma: | |||
*They comprise of haphazardly distributed lamellated bony spicules on a background of fibrous stroma. | |||
*Despite being benign, they can be locally aggressive. | |||
*Immunohistochemical staining of lesions shows positive keratin cells in the majority of the cases. | |||
*The lesion has a zonal architecture with a center of immature bone surrounded by more mature lamellar bone. | |||
*The central spicules of woven bony trabeculae are lined by a layer of osteoblasts. The background is a loose and storiform fibrous tissue. | |||
===Pathogenesis== | |||
*Ossifying fibroma may be either a clonal neoplastic lesion or a developmental dysplasia. | |||
===Associated Conditions=== | |||
*It be related to adamantinoma | |||
==Non-ossifying Fibroma== | |||
===Gross Pathology=== | |||
===Microscopic Pathology=== | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 20:46, 25 February 2016
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Fibroma Microchapters |
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Fibroma pathophysiology On the Web |
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American Roentgen Ray Society Images of Fibroma pathophysiology |
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Risk calculators and risk factors for Fibroma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
On gross pathology, solid white mass which is usually well-circumscribed is characteristic findings of ovarian fibroma. On microscopic histopathological analysis, ovarian fibroma is composed of spindle cells forming variable amounts of collagen. Sectioning of a fibroma typically reveals a chalky-white surface that has a whorled appearance, similar to that of a uterine fibroid. Areas of edema, occasionally with cyst formation, are also relatively common. On gross pathology, polypoid lesion which is usually small, is characteristic findings of oral fibroma. On microscopic histopathological analysis, fibrous stroma, collagen bundles, prominent vessels, and overlying squamous mucosa with hyperkeratosis and focal ulceration are characteristic findings of oral fibroma. On gross pathology, well circumscribed, metaphyseal lesion, and fragments of white-grey rubbery tissue are characteristic findings of chondromyxoid fibroma. On microscopic histopathological analysis, spindle cells or stellate cells in a myxoid or chondroid stroma, lobules with hypocellular centers and hypercellular peripheries, giant cells in a hypercellular periphery, and scattered calcifications are characteristic findings of chondromyxoid fibroma.
Pathophysiology
Ovarian Fibroma
Gross Pathology
On gross pathology, solid white mass which is usually well-circumscribed is characteristic findings of ovarian fibroma.
Microscopic Pathology
On microscopic histopathological analysis, fibroma is composed of spindle cells forming variable amounts of collagen. Sectioning of a fibroma typically reveals a chalky-white surface that has a whorled appearance, similar to that of a uterine fibroid. Areas of edema, occasionally with cyst formation, are also relatively common.
-
Histopathology specimen of an ovarian fibroma high magnification
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Histopathology specimen of an ovarian fibroma intermediate magnification
Oral Fibroma
Gross Pathology
On gross pathology, polypoid lesion which is usually small, is characteristic findings of oral fibroma.
Microscopic Pathology
Following features are noted on microscopic histopathological analysis of oral fibroma:
- Fibrous stroma is a key feature
- Collagen bundles may be present
- Vessels may be prominent
- Overlying squamous mucosa is benign
- Hyperkeratosis may be present
- Focal ulceration may be present
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Histopathology specimen of a oral fibroma low magnification
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Histopathology specimen of a oral fibroma very low magnification
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Histopathology specimen of a oral fibroma intermediate magnification
Chondromyxoid Fibroma
Gross Pathology
On gross pathology, well circumscribed, metaphyseal lesion, and fragments of white-grey rubbery tissue are characteristic findings of chondromyxoid fibroma.
Microscopic Pathology
Following features are noted on microscopic histopathological analysis of chondromyxoid fibroma:
- Spindle cells or stellate cells in a myxoid or chondroid stroma
- Lobules with hypocellular centers and hypercellular peripheries
- Giant cells in the hypercellular periphery
- Scattered calcifications.
- No true hyaline cartilage formation is seen
- No mitotic activity is seen
-
Histopathology specimen of a chondromyxoid fibroma showing stellate cells in myxoid stroma
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Histopathology specimen of a chondromyxoid fibroma showing lobule with calcification
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Histopathology specimen of a chondromyxoid fibroma showing stellate cells in myxohyaline stroma
-
Histopathology specimen of a chondromyxoid fibroma showing stellate cells in myxoid stroma
-
Histopathology specimen of a chondromyxoid fibroma showing focus of amorphous calcification
-
Histopathology specimen of a chondromyxoid fibroma showing foci of amorphous calcification
-
Histopathology specimen of a chondromyxoid fibroma showing stellate cells in myxohyaline stroma
-
Histopathology specimen of a chondromyxoid fibroma showing Lobule with a darker (hypercellular) periphery and lighter (hypocellular) center. (SKB)
.jpg)
Ossifying Fibroma (Osteofibrous dysplasia)
Gross Pathology
On gross pathology, discrete mass that is well delineated from surrounding bone, tan-white, rubbery cut surface, firm to gritty and no encapsulation are characteristic findings of ossifying fibroma.
Microscopic Pathology
Following features are noted on microscopic histopathological analysis of ossifying fibroma:
- They comprise of haphazardly distributed lamellated bony spicules on a background of fibrous stroma.
- Despite being benign, they can be locally aggressive.
- Immunohistochemical staining of lesions shows positive keratin cells in the majority of the cases.
- The lesion has a zonal architecture with a center of immature bone surrounded by more mature lamellar bone.
- The central spicules of woven bony trabeculae are lined by a layer of osteoblasts. The background is a loose and storiform fibrous tissue.
=Pathogenesis
- Ossifying fibroma may be either a clonal neoplastic lesion or a developmental dysplasia.
Associated Conditions
- It be related to adamantinoma