Fibroma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Differential Diagnosis

Type of Fibroma	Differential Diagnosis
Ovarian fibroma	Large pedunculated subserosal uterine leiomyoma Thecoma Leiomyoma Fibrosarcoma Metastatic metaplastic carcinoma Endometriosis with extensive fibrosis.
Non-ossifying fibroma	Fibrous cortical defect Aneurysmal bone cyst Chondromyxoid fibroma Fibrous dysplasia Desmoplastic fibroma Giant cell tumour of bone Spindle cell lesions of bone
Ossifying Fibroma	Fibrous dysplasia Adamantinoma Osteoid osteoma
Chondromyxoid Fibroma	Aneurysmal bone cyst (ABC) Giant cell tumour of bone (GCT) Non ossifying fibroma Chondroblastoma Chondrosarcoma Phosphaturic mesenchymal tumor
Desmoplastic Fibroma	Giant cell tumour of bone (GCT) Non ossifying fibroma (NOF) Fibrous dysplasia Low grade fibrosarcoma.
Pleural Fibroma	Considerations for extremely well defined lesions include: Pleural lipoma Pleural fibrosarcoma Intercostal nerve neurilemoma (schwannoma) If not extremely well defined, broader considerations include: Organised inflammation Peripheral bronchogenic carcinoma Solitary pleural metastasis Also consider the differential for a single pleural mass which includes the following: Pleural tumours Solitary fibrous tumour of the pleura (pleural fibroma) Mesothelioma Localised mediastinal malignant mesothelioma Metastatic pleural disease, particularly from adenocarcinomas Pleural lymphoma Invasive thymoma Lipoma Pleural effusion Empyema Haemothorax Ewing sarcoma of chest wall, Askin tumour Intercostal nerve neurilemmoma Splenosis Tuberculosis
Renal Medullary Fibroma	Renal myxoma
Cemento-ossifying Fibroma	Fibrous dysplasia Ameloblastic fibro odontoma Odontoma Calcifying epithelial odontogenic tumour (Pindborg tumour) Odontogenic cyst Calcifying odontogenic cyst (Gorlin cyst) Osteochondroma Osteosarcoma Chondrosarcoma
Desmoplastic fibroblastoma (Collagenous fibroma)	Fibromatosis Elastofibroma Low-grade fibromyxoid sarcoma.
Ameloblastic Fibroma	Ameloblastoma
Oral Fibroma	Squamous Papilloma