Sickle-cell disease differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Differential Diagnosis

• Sickle cell disease must be differentiated from other diseases that cause fatigue, infection, bone pain, such as:

• thalassemia
• acute leukemia
• autoimmune hemolytic anemia
• HbSC disease
• HbS-beta-thalassemia
• septic arthritis
• polycythemia vera
• systemic lupus erythematosis