Paroxysmal nocturnal hemoglobinuria other diagnostic studies: Difference between revisions

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Revision as of 16:59, 2 July 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There are no other diagnostic studies associated with [disease name].

OR

[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].

OR

Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].

Other Diagnostic Studies

There are no other diagnostic studies associated with [disease name].

OR

[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include:

[Finding 1]
[Finding 2]
[Finding 3]

OR

Other diagnostic studies for [disease name] include:

[Diagnostic study 1], which demonstrates:
- [Finding 1]
- [Finding 2]
- [Finding 3]
[Diagnostic study 2], which demonstrates:
- [Finding 1]
- [Finding 2]
- [Finding 3]

References

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 __NOTOC__
-{{ Paroxysmal nocturnal hemoglobinuria }}
+{{Paroxysmal nocturnal hemoglobinuria}}
-{{CMG}}
+{{CMG}}; {{AE}}
 ==Overview==
+There are no other diagnostic studies associated with [disease name].
+OR
+[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
+OR
+Other diagnostic studies for [disease name] include [diagnostic study 1], which demonstrates [finding 1], [finding 2], and [finding 3], and [diagnostic study 2], which demonstrates [finding 1], [finding 2], and [finding 3].
 ==Other Diagnostic Studies==
-===Flow Cytometry===
-Modern methods include [[flow cytometry]] for [[CD55]], [[CD16]], [[CD59]] and other GPI anchored proteins on [[white blood cells|white]] and[[red blood cells]]. <ref>Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R, Hillmen P, Luzzatto L, Young N, Kinoshita T, Rosse W, Socie G, International PNH Interest Group. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. ''[[Blood (journal)|Blood]]2005;106:3699-709. PMID 16051736.</ref>  Laboratories favor flow cytometry to evaluate PNH due to its high sensitivity and specificity.  Flow cytometry of the peripheral blood, not the bone marrow aspirate, is required to evaluate the presence or absence of GPI linked proteins. The bone marrow biopsy in PNH shows erythroid hyperplasia. In addition, because of the short life of granulocytes, the peripheral blood samples need to reach the lab in an expedited manner.  The most commonly used antibodies are CD59 (expressed on all hematocellular lineages), and CD55 but other GPI anchored antigens (CD14, CD16, CD24) can also be studied on leukocytes.  Dependent on the predominance of these molecules on the red blood cell surface, they are classified as type I, II or III PNH cells.
+There are no other diagnostic studies associated with [disease name].
+OR
+[Diagnostic study] may be helpful in the diagnosis of [disease name]. Findings suggestive of/diagnostic of [disease name] include:
+*[Finding 1]
+*[Finding 2]
+*[Finding 3]
+OR
-PNH type II & III cell populations; definitions.
+Other diagnostic studies for [disease name] include:
-Some patients may have erythrocytes with low but detectable GPI anchored proteins; these cells are designated PNH type II.  By contrast, cells that are completely devoid of GPI anchored proteins are referred to as PNH type III.  Patients with large populations of PNH type II erythrocytes may have less hemolysis than those with comparable populations of PNH III cells but these patients are still at risk for both hemolysis and thrombosis.
+*[Diagnostic study 1], which demonstrates:
+**[Finding 1]
+**[Finding 2]
+**[Finding 3]
+*[Diagnostic study 2], which demonstrates:
+**[Finding 1]
+**[Finding 2]
+**[Finding 3]
 ==References==
 {{Reflist|2}}
-[[Category:Hematology]]
-[[Category:Rheumatology]]
-[[Category:Mature chapter]]
 {{WH}}
 {{WS}}
+[[Category: (name of the system)]]

Paroxysmal nocturnal hemoglobinuria other diagnostic studies: Difference between revisions

Revision as of 16:59, 2 July 2018

Overview

Other Diagnostic Studies

References

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