Multiple sclerosis other diagnostic studies: Difference between revisions

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Revision as of 08:42, 1 March 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Other Diagnostic Studies

Cognition

Neurocognitive testing is important for determining the extent of cognitive deficits. Neuropsychological stimulation may help to reverse or decrease the cognitive defects although its management relies on lifestyle strategies.

Evoked Potential Studies

The brain of a person with MS often responds less actively to stimulation of the optic nerve and sensory nerves. These brain responses can be examined using visual evoked potentials (VEPs) and somatosensory evoked potentials (SEPs). Decreased activity on either test can reveal demyelination which may be otherwise asymptomatic. Along with other data, these exams can help find the widespread nerve involvement required for a definite diagnosis of MS.^[1]

References

↑ Gronseth GS; Ashman EJ. Practice parameter: the usefulness of evoked potentials in identifying clinically silent lesions in patients with suspected multiple sclerosis (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000 May 9;54(9):1720–5. PMID 10802774

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[1] Gronseth GS; Ashman EJ. Practice parameter: the usefulness of evoked potentials in identifying clinically silent lesions in patients with suspected multiple sclerosis (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2000 May 9;54(9):1720–5. PMID 10802774

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 ==Other Diagnostic Studies==
-===CSF Analysis===
-Testing of [[cerebrospinal fluid]] (CSF) can provide evidence of chronic [[inflammation]] of the central nervous system.  The CSF is tested for [[oligoclonal band]]s, which are [[immunoglobulin]]s found in 85% to 95% of people with definite MS (but also found in people with other diseases).<ref>Rudick, RA, Whitaker, JN. ''Cerebrospinal fluid tests for multiple sclerosis.'' In Scheinberg, P (Ed). Neurology/neurosurgery update series, Vol. 7, CPEC. Princeton, NJ 1987</ref> Combined with MRI and clinical data, the presence of oligoclonal bands can help make a definite diagnosis of MS. [[Lumbar puncture]] is the procedure used to collect a sample of CSF.
 ===Cognition===
 [[Neurocognitive]] testing is important for determining the extent of [[cognitive]] deficits. Neuropsychological stimulation may help to reverse or decrease the cognitive defects although its management relies on lifestyle strategies.