Graft-versus-host disease historical perspective: Difference between revisions
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==Historical Perspective== | ==Historical Perspective== | ||
GvHD was recognized many years ago in the 1950s. | |||
*In 1916, GvHD was first observed at the Rockefeller Institute in New York City. An immunologic reaction was noticed after engrafting adult chicken tissue containing T cells onto the chorioamnionic membrane of chick embryos.<ref name="pmid23545575">{{cite journal| author=Barker CF, Markmann JF| title=Historical overview of transplantation. | journal=Cold Spring Harb Perspect Med | year= 2013 | volume= 3 | issue= 4 | pages= a014977 | pmid=23545575 | doi=10.1101/cshperspect.a014977 | pmc=3684003 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23545575 }} </ref> At that time, the concept of T cells was in its infancy. Prior to that time, there was no suggestion of a link between GvHD and T cells.<ref name="pmid23545575">{{cite journal| author=Barker CF, Markmann JF| title=Historical overview of transplantation. | journal=Cold Spring Harb Perspect Med | year= 2013 | volume= 3 | issue= 4 | pages= a014977 | pmid=23545575 | doi=10.1101/cshperspect.a014977 | pmc=3684003 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23545575 }} </ref> | |||
*In 1957, Billingham and Brent noticed unexpected findings. They noticed that mice who were chimeric were becoming very sick and were termed "runts." It was eventually discovered that immunocompetent cells from neonatal inocula could migrate to areas of host lymphoid tissue and mount an attack.<ref name="pmid23545575">{{cite journal| author=Barker CF, Markmann JF| title=Historical overview of transplantation. | journal=Cold Spring Harb Perspect Med | year= 2013 | volume= 3 | issue= 4 | pages= a014977 | pmid=23545575 | doi=10.1101/cshperspect.a014977 | pmc=3684003 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23545575 }} </ref> In the same year, Morton Simonsen showed evidence of GvHD in chickens. He had injected allogeneic lymphoid cells into chick embryos.<ref name="pmid23545575">{{cite journal| author=Barker CF, Markmann JF| title=Historical overview of transplantation. | journal=Cold Spring Harb Perspect Med | year= 2013 | volume= 3 | issue= 4 | pages= a014977 | pmid=23545575 | doi=10.1101/cshperspect.a014977 | pmc=3684003 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23545575 }} </ref> | |||
*In 1959, the work done by Billingham and Brent work was published. | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
Overview
Historical Perspective
GvHD was recognized many years ago in the 1950s.
- In 1916, GvHD was first observed at the Rockefeller Institute in New York City. An immunologic reaction was noticed after engrafting adult chicken tissue containing T cells onto the chorioamnionic membrane of chick embryos.[1] At that time, the concept of T cells was in its infancy. Prior to that time, there was no suggestion of a link between GvHD and T cells.[1]
- In 1957, Billingham and Brent noticed unexpected findings. They noticed that mice who were chimeric were becoming very sick and were termed "runts." It was eventually discovered that immunocompetent cells from neonatal inocula could migrate to areas of host lymphoid tissue and mount an attack.[1] In the same year, Morton Simonsen showed evidence of GvHD in chickens. He had injected allogeneic lymphoid cells into chick embryos.[1]
- In 1959, the work done by Billingham and Brent work was published.