Vitamin B12 deficiency epidemiology and demographics: Difference between revisions
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B12 treatment. | pages=65-71| volume=42 | issue=1 }}</ref> proposed 550 pg/l, and Tiggelen et al <ref>{{cite journal | author=VanTiggelen CJM, Peperkamp JPC, TerToolen JFW. | journal=Journal of Orthomolecular Psychiatry | year=1983 | title=Vitamin-B12 levels of cerebrospinal fluid in patients with organic mental disorder. | pages=305-11 | volume= | issue=12 }}</ref> proposed 600 pg/l. Against this background, there are reasons to believe that B12 deficiency is present in a far greater proportion of the population than 39% as reported by the Tufts University. | B12 treatment. | pages=65-71| volume=42 | issue=1 }}</ref> proposed 550 pg/l, and Tiggelen et al <ref>{{cite journal | author=VanTiggelen CJM, Peperkamp JPC, TerToolen JFW. | journal=Journal of Orthomolecular Psychiatry | year=1983 | title=Vitamin-B12 levels of cerebrospinal fluid in patients with organic mental disorder. | pages=305-11 | volume= | issue=12 }}</ref> proposed 600 pg/l. Against this background, there are reasons to believe that B12 deficiency is present in a far greater proportion of the population than 39% as reported by the Tufts University. | ||
.<ref>{{cite journal | author = Sally P. Stabler and Robert H. Allen(2004)| title = Vitamin B12 Deficiency as a Worldwide Problem. ''Annual Review of Nutrition'' 24: 299-326}}</ref> | |||
B12 deficiency is even more common in the elderly.<ref>{{cite journal | author = H.W. Baik, R.M. Russell (1999)| title = Vitamin b12 deficiency in the elderly. Annual Review of Nutrition 19: 357-377}}</ref> This is because B<sub>12</sub> absorption decreases greatly in the presence of [[atrophic gastritis]], which is common in elderly. | B12 deficiency is even more common in the elderly.<ref>{{cite journal | author = H.W. Baik, R.M. Russell (1999)| title = Vitamin b12 deficiency in the elderly. Annual Review of Nutrition 19: 357-377}}</ref> This is because B<sub>12</sub> absorption decreases greatly in the presence of [[atrophic gastritis]], which is common in elderly. |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
Recent research indicates that B12 deficiency is far more widespread than formerly believed. A large study in the US found that 39 percent had low values.[1] This study at Tufts University used the B12 concentration 258 pmol/l (= 350 pg/liter) as a criterion of "low level". However, recent research has found that B12 deficiency may occur at a much higher B12 concentration (500-600 pg/l). On this basis Mitsuyama and Kogoh [2] proposed 550 pg/l, and Tiggelen et al [3] proposed 600 pg/l. Against this background, there are reasons to believe that B12 deficiency is present in a far greater proportion of the population than 39% as reported by the Tufts University.
.[4]
B12 deficiency is even more common in the elderly.[5] This is because B12 absorption decreases greatly in the presence of atrophic gastritis, which is common in elderly.
References
- ↑ "B12 Deficiency May Be More Widespread Than Thought / August 2, 2000 / News from the USDA Agricultural Research Service". Retrieved 2007-07-01.
- ↑ Mitsuyama Y, Kogoh H. (1988). "Serum and cerebrospinal fluid vitamin B12 levels in demented patients with CH3-
B12 treatment". Japanese Journal of Psychiatry and Neurology. 42 (1): 65–71. line feed character in
|title=
at position 80 (help) - ↑ VanTiggelen CJM, Peperkamp JPC, TerToolen JFW. (1983). "Vitamin-B12 levels of cerebrospinal fluid in patients with organic mental disorder". Journal of Orthomolecular Psychiatry (12): 305–11.
- ↑ Sally P. Stabler and Robert H. Allen(2004). "Vitamin B12 Deficiency as a Worldwide Problem. Annual Review of Nutrition 24: 299-326". soft hyphen character in
|author=
at position 22 (help) - ↑ H.W. Baik, R.M. Russell (1999). "Vitamin b12 deficiency in the elderly. Annual Review of Nutrition 19: 357-377".