Osteoarthritis causes: Difference between revisions
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{{Osteoarthritis}} | {{Osteoarthritis}} | ||
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==Overview== | ==Overview== | ||
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Leg-length inequality > 1 cm is associated with osteoarthritis of the knee.<ref name="pmid20194234">{{cite journal| author=Harvey WF, Yang M, Cooke TD, Segal NA, Lane N, Lewis CE et al.| title=Association of leg-length inequality with knee osteoarthritis: a cohort study. | journal=Ann Intern Med | year= 2010 | volume= 152 | issue= 5 | pages= 287-95 | pmid=20194234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20194234 | doi=10.1059/0003-4819-152-5-201003020-00006 }} </ref> | Leg-length inequality > 1 cm is associated with osteoarthritis of the knee.<ref name="pmid20194234">{{cite journal| author=Harvey WF, Yang M, Cooke TD, Segal NA, Lane N, Lewis CE et al.| title=Association of leg-length inequality with knee osteoarthritis: a cohort study. | journal=Ann Intern Med | year= 2010 | volume= 152 | issue= 5 | pages= 287-95 | pmid=20194234 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20194234 | doi=10.1059/0003-4819-152-5-201003020-00006 }} </ref> | ||
<div style="-webkit-user-select: none;"> | |||
===Common Causes=== | |||
*[[Aseptic necrosis of bone]] | |||
*[[Asymmetric leg length]] | |||
*[[Avascular necrosis]] | |||
*[[Chondrocalcinosis 1 ]] | |||
*[[Chondrocalcinosis 2]] | |||
*[[Developmental dysplasia of the hip]] | |||
*[[Ehlers-danlos syndrome]] | |||
*[[Familial chondrocalcinosis]] | |||
*[[Fracture of bone]] | |||
*[[Joint injury]] | |||
*[[Meniscectomy]] | |||
*[[Multiple epiphyseal dysplasia ]] | |||
*[[Muscle dysfunction]] | |||
*[[Osteochondritis dissecans ]] | |||
*[[Syringomyelia]] | |||
*[[Tabes dorsalis]] | |||
===Causes by Organ System=== | |||
{|style="width:80%; height:100px" border="1" | |||
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular''' | |||
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes | |||
|- | |||
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Dermatologic''' | |||
|bgcolor="Beige"| [[Paget disease]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Drug Side Effect''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ear Nose Throat''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Endocrine''' | |||
|bgcolor="Beige"| [[Acromegaly]], [[Hemochromatosis]], [[Pituitary cancer]], [[Pituitary tumors]], [[Reduced sex hormones]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Environmental''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Gastroenterologic''' | |||
|bgcolor="Beige"| [[Hemochromatosis]], [[Wilson disease]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Genetic''' | |||
|bgcolor="Beige"| [[Adam12]], [[Alkaptonuria ]], [[Asymmetric leg length]], [[Bmp]], [[Clip]], [[Col11a2]], [[Ehlers-danlos syndrome]], [[Erg]], [[Familial chondrocalcinosis]], [[Frzb]], [[Gdf5]], [[Il10]], [[Larsen syndrome ]], [[Mcf2l]], [[Mmp3]], [[Multiple epiphyseal dysplasia ]], [[Nail-patella syndrome ]], [[Osteochondritis dissecans ]], [[Spondyloepiphyseal dysplasia tarda ]], [[Tgfb1]], [[Thalassemia]], [[Wilson disease]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Hematologic''' | |||
|bgcolor="Beige"| [[Diabetes]], [[Hemochromatosis]], [[Thalassemia]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Iatrogenic''' | |||
|bgcolor="Beige"| [[Meniscectomy]], [[Surgery]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Infectious Disease''' | |||
|bgcolor="Beige"| [[Syringomyelia]], [[Tabes dorsalis]], [[Viral hepatitis]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Musculoskeletal/Orthopedic''' | |||
|bgcolor="Beige"| [[Aseptic necrosis of bone]], [[Asymmetric leg length]], [[Avascular necrosis]], [[Chondrocalcinosis 1 ]], [[Chondrocalcinosis 2]], [[Developmental dysplasia of the hip]], [[Ehlers-danlos syndrome]], [[Familial chondrocalcinosis]], [[Fracture of bone]], [[Joint injury]], [[Meniscectomy]], [[Multiple epiphyseal dysplasia ]], [[Muscle dysfunction]], [[Osteochondritis dissecans ]], [[Syringomyelia]], [[Tabes dorsalis]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Neurologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Nutritional/Metabolic''' | |||
|bgcolor="Beige"| [[Diabetes]], [[Obesity]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Obstetric/Gynecologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Oncologic''' | |||
|bgcolor="Beige"| [[Pituitary cancer]], [[Pituitary tumors]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Ophthalmologic''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Overdose/Toxicity''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Psychiatric''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Pulmonary''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Renal/Electrolyte''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Rheumatology/Immunology/Allergy''' | |||
|bgcolor="Beige"| [[Allergies]], [[Aseptic necrosis of bone]], [[Avascular necrosis]], [[Chondrocalcinosis 1 ]], [[Chondrocalcinosis 2]], [[Crystal deposition]], [[Gout]], [[Lupus]], [[Rheumatoid arthritis]], [[Satoyoshi syndrome]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Sexual''' | |||
|bgcolor="Beige"| No underlying causes | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Trauma''' | |||
|bgcolor="Beige"| [[Developmental dysplasia of the hip]], [[Fracture of bone]], [[Joint injury]], [[Physical trauma]], [[Trauma]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Urologic''' | |||
|bgcolor="Beige"| [[Alkaptonuria ]] | |||
|- | |||
|-bgcolor="LightSteelBlue" | |||
| '''Miscellaneous''' | |||
|bgcolor="Beige"| [[Aging]] | |||
|- | |||
|} | |||
===Causes in Alphabetical Order=== | |||
{{columns-list|3| | |||
*[[Acromegaly]] | |||
*[[Adam12]] | |||
*[[Aging]] | |||
*[[Alkaptonuria ]] | |||
*[[Allergies]] | |||
*[[Aseptic necrosis of bone]] | |||
*[[Asymmetric leg length]] | |||
*[[Avascular necrosis]] | |||
*[[Bmp]] | |||
*[[Chondrocalcinosis 1 ]] | |||
*[[Chondrocalcinosis 2]] | |||
*[[Clip]] | |||
*[[Col11a2]] | |||
*[[Crystal deposition]] | |||
*[[Developmental dysplasia of the hip]] | |||
*[[Diabetes]] | |||
*[[Ehlers-danlos syndrome]] | |||
*[[Erg]] | |||
*[[Familial chondrocalcinosis]] | |||
*[[Fracture of bone]] | |||
*[[Frzb]] | |||
*[[Gdf5]] | |||
*[[Gout]] | |||
*[[Hemochromatosis]] | |||
*[[Il10]] | |||
*[[Joint injury]] | |||
*[[Larsen syndrome ]] | |||
*[[Lupus]] | |||
*[[Mcf2l]] | |||
*[[Meniscectomy]] | |||
*[[Mmp3]] | |||
*[[Multiple epiphyseal dysplasia ]] | |||
*[[Muscle dysfunction]] | |||
*[[Nail-patella syndrome ]] | |||
*[[Obesity]] | |||
*[[Osteochondritis dissecans ]] | |||
*[[Paget disease]] | |||
*[[Physical trauma]] | |||
*[[Pituitary cancer]] | |||
*[[Pituitary tumors]] | |||
*[[Reduced sex hormones]] | |||
*[[Rheumatoid arthritis]] | |||
*[[Satoyoshi syndrome]] | |||
*[[Spondyloepiphyseal dysplasia tarda ]] | |||
*[[Surgery]] | |||
*[[Syringomyelia]] | |||
*[[Tabes dorsalis]] | |||
*[[Tgfb1]] | |||
*[[Thalassemia]] | |||
*[[Trauma]] | |||
*[[Viral hepatitis]] | |||
*[[Wilson disease]] | |||
}} | |||
</div> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} |
Revision as of 20:09, 10 January 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Robert G. Badgett, M.D. [2] Luke Rusowicz-Orazem, B.S.
Overview
Causes
Osteoarthritis often affects multiple members of the same family, suggesting that there is hereditary susceptibility to this condition. A number of studies have shown that there is a greater prevalence of the disease between siblings and especially identical twins, indicating a hereditary basis. Up to 60% of OA cases are thought to result from genetic factors. Researchers are also investigating the possibility of allergies, infections, or fungi as a cause. There is some evidence that allergies, whether fungal, infectious or systemically induced, may be a significant contributing factor to the appearance of osteoarthritis in a synovial sac. Randomized, controlled studies have shown a 40% reduction in joint degeneration if Tetracycline derivative antibiotics are taken consistently over time.
Obesity may contribute to osteoarthritis of the knee.[1][2][3]
Leg-length inequality > 1 cm is associated with osteoarthritis of the knee.[4]
Common Causes
- Aseptic necrosis of bone
- Asymmetric leg length
- Avascular necrosis
- Chondrocalcinosis 1
- Chondrocalcinosis 2
- Developmental dysplasia of the hip
- Ehlers-danlos syndrome
- Familial chondrocalcinosis
- Fracture of bone
- Joint injury
- Meniscectomy
- Multiple epiphyseal dysplasia
- Muscle dysfunction
- Osteochondritis dissecans
- Syringomyelia
- Tabes dorsalis
Causes by Organ System
Causes in Alphabetical Order
References
- ↑ Nguyen US, Zhang Y, Zhu Y, Niu J, Zhang B, Felson DT (2011). "Increasing prevalence of knee pain and symptomatic knee osteoarthritis: survey and cohort data". Ann Intern Med. 155 (11): 725–32. doi:10.1059/0003-4819-155-11-201112060-00004. PMC 3408027. PMID 22147711.
- ↑ McAlindon TE, Wilson PW, Aliabadi P, Weissman B, Felson DT (1999). "Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: the Framingham study". Am J Med. 106 (2): 151–7. PMID 10230743.
- ↑ Hart DJ, Doyle DV, Spector TD (1999). "Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study". Arthritis Rheum. 42 (1): 17–24. doi:10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E. PMID 9920009.
- ↑ Harvey WF, Yang M, Cooke TD, Segal NA, Lane N, Lewis CE; et al. (2010). "Association of leg-length inequality with knee osteoarthritis: a cohort study". Ann Intern Med. 152 (5): 287–95. doi:10.1059/0003-4819-152-5-201003020-00006. PMID 20194234.