Autoimmune hepatitis classification: Difference between revisions
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==Classification== | ==Classification== | ||
According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below: | |||
* | *AIH-1: | ||
* | **Common type of AIH (accounts almost for 90% of AIH cases) | ||
**Presents at any age | |||
**Detection of ANA, SMA | |||
or anti-SLA/LP; | |||
**Association with HLA DR3, DR4, and DR13; any age at onset of variable clinical and | |||
histopathological severity; rare failure of treatment but variable relapse rates after drug withdrawal and | |||
variable need for long-term maintenance therapy | |||
• AIH-2: accounts for up to 10% of AIH cases; detection of anti-LKM1, anti-LC1 and rarely anti- | |||
LKM3; association with HLA DR3 and DR7; onset usually in childhood and young adulthood; clinical | |||
and histopathological severity commonly acute and advanced; frequent failure of treatment and frequent | |||
relapse rates after drug withdrawal; the need for long-term maintenance therapy very common | |||
• AIH-3: SLA/LP positive, otherwise very similar to AIH-1; often Ro52-antibody positive. Possibly more | |||
severe | |||
==References== | ==References== | ||
Revision as of 17:37, 5 December 2017
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Autoimmune hepatitis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Autoimmune hepatitis classification On the Web |
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American Roentgen Ray Society Images of Autoimmune hepatitis classification |
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Risk calculators and risk factors for Autoimmune hepatitis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
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Overview
Classification
According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below:
- AIH-1:
- Common type of AIH (accounts almost for 90% of AIH cases)
- Presents at any age
- Detection of ANA, SMA
or anti-SLA/LP;
- Association with HLA DR3, DR4, and DR13; any age at onset of variable clinical and
histopathological severity; rare failure of treatment but variable relapse rates after drug withdrawal and variable need for long-term maintenance therapy • AIH-2: accounts for up to 10% of AIH cases; detection of anti-LKM1, anti-LC1 and rarely anti- LKM3; association with HLA DR3 and DR7; onset usually in childhood and young adulthood; clinical and histopathological severity commonly acute and advanced; frequent failure of treatment and frequent relapse rates after drug withdrawal; the need for long-term maintenance therapy very common • AIH-3: SLA/LP positive, otherwise very similar to AIH-1; often Ro52-antibody positive. Possibly more severe