Sickle-cell disease risk factors: Difference between revisions
Shyam Patel (talk | contribs) No edit summary |
Shyam Patel (talk | contribs) No edit summary |
||
| Line 7: | Line 7: | ||
==Risk Factors== | ==Risk Factors== | ||
Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.<ref name="pmid25143960">{{cite journal| author=Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K| title=Sickle cell disease: new opportunities and challenges in Africa. | journal=ScientificWorldJournal | year= 2013 | volume= 2013 | issue= | pages= 193252 | pmid=25143960 | doi=10.1155/2013/193252 | pmc=3988892 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143960 }} </ref> | Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.<ref name="pmid25143960">{{cite journal| author=Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K| title=Sickle cell disease: new opportunities and challenges in Africa. | journal=ScientificWorldJournal | year= 2013 | volume= 2013 | issue= | pages= 193252 | pmid=25143960 | doi=10.1155/2013/193252 | pmc=3988892 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25143960 }} </ref> The degree of fetal hemoglobin production is related to the severe of disease: higher fetal hemoglobin confers lower disease morbidity and thus is a favorable risk factor/modifier.<ref name="pmid22887019">{{cite journal| author=Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L et al.| title=A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease. | journal=Am J Hematol | year= 2012 | volume= 87 | issue= 11 | pages= 1017-21 | pmid=22887019 | doi=10.1002/ajh.23306 | pmc=3904792 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22887019 }} </ref> | ||
There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence. | There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence. | ||
Revision as of 03:14, 25 September 2016
|
Sickle-cell disease Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Sickle-cell disease risk factors On the Web |
|
American Roentgen Ray Society Images of Sickle-cell disease risk factors |
|
Risk calculators and risk factors for Sickle-cell disease risk factors |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
There are no specific risk factors for sickle cell disease.
Risk Factors
Besides race, there are no specific risk factors for sickle cell disease. Sickle cell disease is a monogenetic disease, meaning that one gene mutations causes the disease. Thus environmental factors do not play a major role in acquisition of the disease. The disease occurs at birth after a person inherits 2 sickle cell alleles, one from each parent. Certain endemic regions contain a high prevalence of sickle cell alleles.[1] The degree of fetal hemoglobin production is related to the severe of disease: higher fetal hemoglobin confers lower disease morbidity and thus is a favorable risk factor/modifier.[2]
There are some risk factors for precipitation of sickle cell crises, such as dehydration, low oxygen levels, medication nonadherence.
References
- ↑ Makani J, Ofori-Acquah SF, Nnodu O, Wonkam A, Ohene-Frempong K (2013). "Sickle cell disease: new opportunities and challenges in Africa". ScientificWorldJournal. 2013: 193252. doi:10.1155/2013/193252. PMC 3988892. PMID 25143960.
- ↑ Kutlar A, Ataga K, Reid M, Vichinsky EP, Neumayr L, Blair-Britt L; et al. (2012). "A phase 1/2 trial of HQK-1001, an oral fetal globin inducer, in sickle cell disease". Am J Hematol. 87 (11): 1017–21. doi:10.1002/ajh.23306. PMC 3904792. PMID 22887019.