Neutropenia pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
==Pathophysiology== | ==Pathophysiology== | ||
Neutropenia | ===Pathogenesis=== | ||
Neutropenia may develop as a result of one of the three mechanisms: | |||
'''1) Impaired [[granulocyte]] production''' | |||
*[[Hematologic]] [[malignancy]] with [[bone marrow]] infiltration | |||
*Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow | |||
*Nutritional deficiencies | |||
'''2) Margination''' (process where free flowing blood cells exit circulation) | '''2) Margination''' (process where free flowing blood cells exit circulation) | ||
*Splenic sequestration | |||
*Adherence to the [[vascular]] [[endothelium]] | |||
'''3) Peripheral destruction''' | '''3) Peripheral destruction''' | ||
- Autoimmune [[hemolysis]] | - Autoimmune [[hemolysis]] | ||
- Drug-induced [[hemolysis]] | |||
===Genetics=== | |||
Genes involved in the pathogenesis of neutropenia include ''ELA2'', ''HAX1'', and ''CXCR4''. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:41, 10 October 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
Pathophysiology
Pathogenesis
Neutropenia may develop as a result of one of the three mechanisms:
1) Impaired granulocyte production
- Hematologic malignancy with bone marrow infiltration
- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow
- Nutritional deficiencies
2) Margination (process where free flowing blood cells exit circulation)
- Splenic sequestration
- Adherence to the vascular endothelium
3) Peripheral destruction - Autoimmune hemolysis - Drug-induced hemolysis
Genetics
Genes involved in the pathogenesis of neutropenia include ELA2, HAX1, and CXCR4.