Focal segmental glomerulosclerosis overview: Difference between revisions
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The individual components of the name refer to the appearance of the kidney tissue on [[biopsy]]: ''focal'' - only some of the [[glomerulus|glomeruli]] are involved (as opposed to diffuse), ''segmental'' - only part of an entire glomerulus is involved (as opposed to global), ''glomerulosclerosis'' - refers to scarring of the [[glomerulus]] (a part of the [[nephron]] (the functional unit of the [[kidney]])). | The individual components of the name refer to the appearance of the kidney tissue on [[biopsy]]: ''focal'' - only some of the [[glomerulus|glomeruli]] are involved (as opposed to diffuse), ''segmental'' - only part of an entire glomerulus is involved (as opposed to global), ''glomerulosclerosis'' - refers to scarring of the [[glomerulus]] (a part of the [[nephron]] (the functional unit of the [[kidney]])). | ||
FSGS is a progressive form of renal disease, it has become the most common cause of GN-related ESRD in patients with End Stage Renal Disease (ESRD) in the United States <ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> | FSGS is a progressive form of renal disease, it has become the most common cause of GN-related ESRD in patients with End Stage Renal Disease (ESRD) in the United States. <ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> It accounts for about 40% of adults and about 20% of pediatric cases of Nephrotic Syndrome in the United States <ref name="pmid15492947">{{cite journal| author=Kitiyakara C, Eggers P, Kopp JB| title=Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States. | journal=Am J Kidney Dis | year= 2004 | volume= 44 | issue= 5 | pages= 815-25 | pmid=15492947 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15492947 }} </ref> | ||
Revision as of 15:43, 18 October 2016
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Focal segmental glomerulosclerosis Microchapters |
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Differentiating Focal segmental glomerulosclerosis from other Diseases |
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Diagnosis |
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Focal segmental glomerulosclerosis overview On the Web |
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Directions to Hospitals Treating Focal segmental glomerulosclerosis |
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Risk calculators and risk factors for Focal segmental glomerulosclerosis overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief:’’’ Cafer Zorkun, M.D., Ph.D. [2]Olufunmilola Olubukola M.D.[3]
Overview
Focal segmental glomerulosclerosis (FSGS) is a cause of nephrotic syndrome in children and adolescents, as well as an important cause of kidney failure in adults.[1] Focal Segmental Glomerulosclerosis (FSGS) is a distinct finding and a descriptive report on the glomerular morphology seen in certain glomerular disease conditions. It is considered to be a glomerular podocytopathy [2]. Minimal change disease (MCD) is by far the most common cause of nephrotic syndrome in children: MCD and primary FSGS may have a similar cause.[1]
The individual components of the name refer to the appearance of the kidney tissue on biopsy: focal - only some of the glomeruli are involved (as opposed to diffuse), segmental - only part of an entire glomerulus is involved (as opposed to global), glomerulosclerosis - refers to scarring of the glomerulus (a part of the nephron (the functional unit of the kidney)).
FSGS is a progressive form of renal disease, it has become the most common cause of GN-related ESRD in patients with End Stage Renal Disease (ESRD) in the United States. [3] It accounts for about 40% of adults and about 20% of pediatric cases of Nephrotic Syndrome in the United States [3]
References
- ↑ 1.0 1.1 Kumar V, Fausto N, Abbas A (editors) (2003). Robbins & Cotran Pathologic Basis of Disease (7th ed.). Saunders. pp. pp. 982-3. ISBN 978-0-721-60187-8.
- ↑ Sethi S, Glassock RJ, Fervenza FC (2015). "Focal segmental glomerulosclerosis: towards a better understanding for the practicing nephrologist". Nephrol Dial Transplant. 30 (3): 375–84. doi:10.1093/ndt/gfu035. PMID 24589721 PMID: 24589721 Check
|pmid=value (help). - ↑ 3.0 3.1 Kitiyakara C, Eggers P, Kopp JB (2004). "Twenty-one-year trend in ESRD due to focal segmental glomerulosclerosis in the United States". Am J Kidney Dis. 44 (5): 815–25. PMID 15492947.