Neutropenia pathophysiology: Difference between revisions
No edit summary |
mNo edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
Neutropenia may develop as a result of one of the three mechanisms: | Neutropenia may develop as a result of one of the three mechanisms: impaired [[granulocyte]] production, margination, and peripheral destruction. Genes involved in the pathogenesis of neutropenia include ''ELA2'', ''[[HAX1]]'', and ''[[CXCR4]]''. | ||
==Pathophysiology== | ==Pathophysiology== | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
Neutropenia may develop as a result of one of the three mechanisms<ref name="PMID17379162">{{cite journal |author=Schwartzberg LS. |title=Neutropenia: etiology and pathogenesis.|journal=Clin Cornerstone. |volume=8|issue=5 |pages=5-11|year=2006|pmid 17379162|doi=|url=https://www.ncbi.nlm.nih.gov/pubmed/17379162}}</ref> | Neutropenia may develop as a result of one of the three mechanisms:<ref name="PMID17379162">{{cite journal |author=Schwartzberg LS. |title=Neutropenia: etiology and pathogenesis.|journal=Clin Cornerstone. |volume=8|issue=5 |pages=5-11|year=2006|pmid 17379162|doi=|url=https://www.ncbi.nlm.nih.gov/pubmed/17379162}}</ref> | ||
'''1) Impaired [[granulocyte]] production''' | '''1) Impaired [[granulocyte]] production''' | ||
| Line 24: | Line 24: | ||
===Genetics=== | ===Genetics=== | ||
Genes involved in the pathogenesis of neutropenia include ''ELA2'', ''HAX1'', and ''CXCR4''. | Genes involved in the pathogenesis of neutropenia include ''ELA2'', ''[[HAX1]]'', and ''[[CXCR4]]''. | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:08, 9 November 2016
|
Neutropenia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Neutropenia pathophysiology On the Web |
|
American Roentgen Ray Society Images of Neutropenia pathophysiology |
|
Risk calculators and risk factors for Neutropenia pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Daniel A. Gerber, M.D. [2]
Overview
Neutropenia may develop as a result of one of the three mechanisms: impaired granulocyte production, margination, and peripheral destruction. Genes involved in the pathogenesis of neutropenia include ELA2, HAX1, and CXCR4.
Pathophysiology
Pathogenesis
Neutropenia may develop as a result of one of the three mechanisms:[1]
1) Impaired granulocyte production
- Hematologic malignancy with bone marrow infiltration
- Myelosuppressive chemotherapy or other medications that are toxic to the bone marrow
- Nutritional deficiencies
2) Margination (process where free flowing blood cells exit circulation)
- Splenic sequestration
- Adherence to the vascular endothelium
3) Peripheral destruction
Genetics
Genes involved in the pathogenesis of neutropenia include ELA2, HAX1, and CXCR4.
References
- ↑ Schwartzberg LS. (2006). "Neutropenia: etiology and pathogenesis". Clin Cornerstone. 8 (5): 5–11. Text "pmid 17379162" ignored (help)