Cytomegalovirus infection laboratory findings: Difference between revisions
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*[[PCR]] for demonstration of [[CMV]] [[DNA]] is useful for the diagnosis of [[retinitis]] and neurologic disease. | *[[PCR]] for demonstration of [[CMV]] [[DNA]] is useful for the diagnosis of [[retinitis]] and neurologic disease. | ||
*[[PCR]] of [[blood]] for demonstration of [[viremia]] is not useful for diagnosis of [[cytomegalovirus]] end organ disease as a negative result is not consistent with the absence of disease. | *[[PCR]] of [[blood]] for demonstration of [[viremia]] is not useful for diagnosis of [[cytomegalovirus]] end organ disease as a negative result is not consistent with the absence of disease. | ||
==References== | |||
Revision as of 14:21, 24 May 2017
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Cytomegalovirus infection Microchapters |
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Differentiating Cytomegalovirus infection from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Cytomegalovirus infection laboratory findings On the Web |
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American Roentgen Ray Society Images of Cytomegalovirus infection laboratory findings |
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Risk calculators and risk factors for Cytomegalovirus infection laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]
Overview
There are no specific laboratory findings associated with CMV infection. Elevated ESR and a low lymphocyte count may be present in patients with complications. Diagnosis is usually done by demonstration of the inclusion bodies from the tissue biopsies or by a positive PCR for CMV DNA.
Laboratory Findings
The following laboratory investigations are useful for the diagnosis of cytomegalovirus infection:
Serological Tests
- Serological tests are not useful for the diagnosis of cytomegalovirus infection, however absence of CMV IgG excludes the presence of infection.
Polymerase Chain Reaction
- In patients with cytomegalovirus retinitis CMV DNA is detected in the vitreous in majority of patients.
- PCR for demonstration of CMV DNA is useful for the diagnosis of retinitis and neurologic disease.
- PCR of blood for demonstration of viremia is not useful for diagnosis of cytomegalovirus end organ disease as a negative result is not consistent with the absence of disease.