Graft-versus-host disease physical examination: Difference between revisions
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==Physical Examination== | ==Physical Examination== | ||
*Skin: Exam findings include erythema, maculopapular rash, and hyperpigmentation.<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139 }} </ref> | *Skin: Exam findings include erythema, maculopapular rash, and hyperpigmentation.<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139 }} </ref> Lichen planus-like lesions have been observed in skin GvHD.<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139 }} </ref> | ||
*Liver: Exam findings include jaundice, pruritis, leg swelling, tenderness in the right upper quadrant of the abdomen, bleeding from coagulopathy. The classic physical exam findings are suggestive of cholestatic hepatitis.<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139 }} </ref> | *Liver: Exam findings include jaundice, pruritis, leg swelling, tenderness in the right upper quadrant of the abdomen, bleeding from coagulopathy. The classic physical exam findings are suggestive of cholestatic hepatitis.<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139 }} </ref> | ||
Revision as of 02:36, 18 June 2017
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Graft-versus-host disease physical examination On the Web |
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American Roentgen Ray Society Images of Graft-versus-host disease physical examination |
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Risk calculators and risk factors for Graft-versus-host disease physical examination |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The physical exam for GvHD focuses on the organ involved, including the skin, liver, and GI tract.
Physical Examination
- Skin: Exam findings include erythema, maculopapular rash, and hyperpigmentation.[1] Lichen planus-like lesions have been observed in skin GvHD.[1]
- Liver: Exam findings include jaundice, pruritis, leg swelling, tenderness in the right upper quadrant of the abdomen, bleeding from coagulopathy. The classic physical exam findings are suggestive of cholestatic hepatitis.[1]
- GI tract: Exam findings include abdominal tenderness, diarrhea, hyperactive or hypoactive bowel sounds.
References
- ↑ 1.0 1.1 1.2 Socié G, Ritz J (2014). "Current issues in chronic graft-versus-host disease". Blood. 124 (3): 374–84. doi:10.1182/blood-2014-01-514752. PMC 4102710. PMID 24914139.