Graft-versus-host disease other imaging findings: Difference between revisions
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==Other Imaging Findings== | ==Other Imaging Findings== | ||
Imaging modalities have been used to diagnose GvHD, as certain radiographic features can suggest for or against a diagnosis of GvHD. However, radiographic findings are non-specific, as these can be found in various other diseases. | |||
*Abdominal plain films (abdominal X-rays) were used in the 1980s in an attempt to diagnose GvHD. It was noted in 1988 that 95% of patients had separation of bowel loops on abdominal X-ray, suggesting wall thickening, air fluid levels, or dilatation of the small bowel.<ref name="pmid24733964">{{cite journal| author=Malard F, Mohty M| title=New insight for the diagnosis of gastrointestinal acute graft-versus-host disease. | journal=Mediators Inflamm | year= 2014 | volume= 2014 | issue= | pages= 701013 | pmid=24733964 | doi=10.1155/2014/701013 | pmc=3964897 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24733964 }} </ref> | |||
*CT scans has been used to diagnose GvHD: radiographic features include bowel wall thickening and mucosal enhancement. Acute GvHD tends to present radiographically with moderate bowel wall thickening.<ref name="pmid24733964">{{cite journal| author=Malard F, Mohty M| title=New insight for the diagnosis of gastrointestinal acute graft-versus-host disease. | journal=Mediators Inflamm | year= 2014 | volume= 2014 | issue= | pages= 701013 | pmid=24733964 | doi=10.1155/2014/701013 | pmc=3964897 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24733964 }} </ref> However, these radiographic features are also common to [[Clostridium difficile]] colitis.<ref name="pmid24733964">{{cite journal| author=Malard F, Mohty M| title=New insight for the diagnosis of gastrointestinal acute graft-versus-host disease. | journal=Mediators Inflamm | year= 2014 | volume= 2014 | issue= | pages= 701013 | pmid=24733964 | doi=10.1155/2014/701013 | pmc=3964897 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24733964 }} </ref> [[C. difficile]] or CMV colitis tends to present with severe bowel wall thickening. | |||
*MRI can be used though this test is highly expensive and cost-ineffective relative to the diagnostic yield. MRI of the abdomen would should bowel wall thickening and mucosal enhancement with gadolinium.<ref name="pmid24733964">{{cite journal| author=Malard F, Mohty M| title=New insight for the diagnosis of gastrointestinal acute graft-versus-host disease. | journal=Mediators Inflamm | year= 2014 | volume= 2014 | issue= | pages= 701013 | pmid=24733964 | doi=10.1155/2014/701013 | pmc=3964897 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24733964 }} </ref> | |||
==References== | ==References== | ||
Revision as of 18:19, 20 June 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
Other Imaging Findings
Imaging modalities have been used to diagnose GvHD, as certain radiographic features can suggest for or against a diagnosis of GvHD. However, radiographic findings are non-specific, as these can be found in various other diseases.
- Abdominal plain films (abdominal X-rays) were used in the 1980s in an attempt to diagnose GvHD. It was noted in 1988 that 95% of patients had separation of bowel loops on abdominal X-ray, suggesting wall thickening, air fluid levels, or dilatation of the small bowel.[1]
- CT scans has been used to diagnose GvHD: radiographic features include bowel wall thickening and mucosal enhancement. Acute GvHD tends to present radiographically with moderate bowel wall thickening.[1] However, these radiographic features are also common to Clostridium difficile colitis.[1] C. difficile or CMV colitis tends to present with severe bowel wall thickening.
- MRI can be used though this test is highly expensive and cost-ineffective relative to the diagnostic yield. MRI of the abdomen would should bowel wall thickening and mucosal enhancement with gadolinium.[1]