Systemic lupus erythematosus laboratory tests: Difference between revisions
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|Antiphospholipid antibodies | |Antiphospholipid antibodies | ||
16420554 | <ref name="pmid16420554">{{cite journal |vauthors=Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA |title=International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) |journal=J. Thromb. Haemost. |volume=4 |issue=2 |pages=295–306 |year=2006 |pmid=16420554 |doi=10.1111/j.1538-7836.2006.01753.x |url=}}</ref> | ||
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* Lupus anticoagulant [LA] | * Lupus anticoagulant [LA] | ||
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|complement levels | |complement levels | ||
18075790 | <ref name="pmid18075790">{{cite journal |vauthors=Truedsson L, Bengtsson AA, Sturfelt G |title=Complement deficiencies and systemic lupus erythematosus |journal=Autoimmunity |volume=40 |issue=8 |pages=560–6 |year=2007 |pmid=18075790 |doi=10.1080/08916930701510673 |url=}}</ref> | ||
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* C3: vary between varying between normal to slightly reduced | * C3: vary between varying between normal to slightly reduced | ||
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|Anti-Ro/SSA antibodies | |Anti-Ro/SSA antibodies | ||
15593352 | <ref name="pmid15593352">{{cite journal |vauthors=Benito-Garcia E, Schur PH, Lahita R |title=Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-Sm and anti-RNP antibody tests |journal=Arthritis Rheum. |volume=51 |issue=6 |pages=1030–44 |year=2004 |pmid=15593352 |doi=10.1002/art.20836 |url=}}</ref> | ||
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|anti-La/SSB antibodies | |anti-La/SSB antibodies | ||
15593352 | <ref name="pmid15593352">{{cite journal |vauthors=Benito-Garcia E, Schur PH, Lahita R |title=Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-Sm and anti-RNP antibody tests |journal=Arthritis Rheum. |volume=51 |issue=6 |pages=1030–44 |year=2004 |pmid=15593352 |doi=10.1002/art.20836 |url=}}</ref> | ||
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|Anti-U1 RNP antibodies | |Anti-U1 RNP antibodies | ||
15593352 | <ref name="pmid15593352">{{cite journal |vauthors=Benito-Garcia E, Schur PH, Lahita R |title=Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-Sm and anti-RNP antibody tests |journal=Arthritis Rheum. |volume=51 |issue=6 |pages=1030–44 |year=2004 |pmid=15593352 |doi=10.1002/art.20836 |url=}}</ref> | ||
|Elevated | |Elevated | ||
| colspan="2" | | | colspan="2" | | ||
Revision as of 21:21, 22 June 2017
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Systemic lupus erythematosus Microchapters |
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Differentiating Systemic lupus erythematosus from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: {{MIR}
Overview
Laboratory findings consistent with the diagnosis of systemic lupus erythematosus include anemia, leukopenia or lymphopenia, elevated levels of ANA, anti-dsDNA, anti-SM and antiphospholipid, and decrease of complement levels.
Laboratory tests
Laboratory findings consistent with the diagnosis of systemic lupus erythematosus include anemia, leukopenia or lymphopenia, elevated levels of ANA, anti-dsDNA, anti-SM and antiphospholipid, and decrease of complement levels.
| Lab exam | result | clinical correlation | ||
|---|---|---|---|---|
| Hematology | Complete blood count |
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| Serum creatinine | Elevated |
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| Urine | Urinalysis
Urine sediment |
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| Serology | ANA | Elevated |
| |
| Antiphospholipid antibodies |
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| complement levels |
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| Erythrocyte sedimentation rate (ESR) | Elevated | |||
| C-reactive protein (CRP) | Elevated | |||
| Urine protein-to-creatinine ratio | Elevated | |||
| Anti-dsDNA | Elevated |
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| anti-Sm antibodies | Elevated |
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| Anti-Ro/SSA antibodies | Elevated |
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| anti-La/SSB antibodies | Elevated |
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| Anti-U1 RNP antibodies | Elevated |
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| Antiribosomal P protein antibodies | Elevated |
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| Direct Coombs' test | Positive |
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If the initial ANA test is negative, but the clinical suspicion of SLE is high, then additional antibody testing may still be appropriate. This is partly related to the differences in the sensitivity and specificity among the methods used to detect ANA.
Laboratory exams to distinguish SLE from other diseases
| Test | Interpretation |
|---|---|
| anti-cyclic citrullinated peptide (CCP) antibodies |
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| Rheumatoid factor (RF) |
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| Serological studies for infection |
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| Creatine kinase (CK) |
|
References
- ↑ Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA (2006). "International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)". J. Thromb. Haemost. 4 (2): 295–306. doi:10.1111/j.1538-7836.2006.01753.x. PMID 16420554.
- ↑ Truedsson L, Bengtsson AA, Sturfelt G (2007). "Complement deficiencies and systemic lupus erythematosus". Autoimmunity. 40 (8): 560–6. doi:10.1080/08916930701510673. PMID 18075790.
- ↑ 3.0 3.1 3.2 Benito-Garcia E, Schur PH, Lahita R (2004). "Guidelines for immunologic laboratory testing in the rheumatic diseases: anti-Sm and anti-RNP antibody tests". Arthritis Rheum. 51 (6): 1030–44. doi:10.1002/art.20836. PMID 15593352.