Graft-versus-host disease differential diagnosis: Difference between revisions
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==Differential Diagnosis== | ==Differential Diagnosis== | ||
The differential diagnosis for GvHD can be categorized into the specific organs involved. When a post-transplant patient develops liver, GI, or skin symptoms, there are numerous possibilities regarding the etiology, as post-transplant patients are immunocompromised and at risk for infections. The clinical manifestations of infection in the liver, GI | The differential diagnosis for GvHD can be categorized into the specific organs involved. When a post-transplant patient develops liver, [[Gastrointestinal tract|GI,]] or [[skin]] symptoms, there are numerous possibilities regarding the etiology, as post-transplant patients are immunocompromised and at risk for infections. The clinical manifestations of infection in the [[liver]], [[Gastrointestinal tract|GI trac]]<nowiki/>t, and [[skin]] can mimic symptoms of GvHD. | ||
For liver signs and symptoms, differential diagnosis includes: | For [[liver]] signs and symptoms, differential diagnosis includes: | ||
*[[CMV]] hepatitis<ref name="pmid26729898">{{cite journal| author=McDonald GB| title=How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. | journal=Blood | year= 2016 | volume= 127 | issue= 12 | pages= 1544-50 | pmid=26729898 | doi=10.1182/blood-2015-10-612747 | pmc=4807421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26729898 }} </ref> | *[[CMV]] hepatitis<ref name="pmid26729898">{{cite journal| author=McDonald GB| title=How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. | journal=Blood | year= 2016 | volume= 127 | issue= 12 | pages= 1544-50 | pmid=26729898 | doi=10.1182/blood-2015-10-612747 | pmc=4807421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26729898 }} </ref> | ||
*[[Sinusoidal obstruction syndrome]] ([[hepatic veno-occlusive disease]]) | *[[Sinusoidal obstruction syndrome]] ([[hepatic veno-occlusive disease]]) | ||
*Viral hepatitis<ref name="pmid26729898">{{cite journal| author=McDonald GB| title=How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. | journal=Blood | year= 2016 | volume= 127 | issue= 12 | pages= 1544-50 | pmid=26729898 | doi=10.1182/blood-2015-10-612747 | pmc=4807421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26729898 }} </ref> | *[[Viral hepatitis]]<ref name="pmid26729898">{{cite journal| author=McDonald GB| title=How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver. | journal=Blood | year= 2016 | volume= 127 | issue= 12 | pages= 1544-50 | pmid=26729898 | doi=10.1182/blood-2015-10-612747 | pmc=4807421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26729898 }} </ref> | ||
*[[Cholelithiasis]] | *[[Cholelithiasis]] | ||
*[[Choledocholithiasis]] | *[[Choledocholithiasis]] | ||
For gastrointestinal signs and symptoms, differential diagnosis includes: | For [[Gastrointestinal tract|gastrointestinal]] signs and symptoms, differential diagnosis includes: | ||
*[[Typhilitis]] (neutropenic enterocolitis) | *[[Typhilitis]] (neutropenic enterocolitis) | ||
| Line 24: | Line 24: | ||
*[[Ischemic colitis]] | *[[Ischemic colitis]] | ||
For skin signs and symptoms, differential diagnosis includes: | For [[skin]] signs and symptoms, differential diagnosis includes: | ||
*[[Varicella zoster]] (shingles) | *[[Varicella zoster]] ([[shingles]]) | ||
*[[Bacterial cellulitis]] | *[[Cellulitis|Bacterial cellulitis]] | ||
*[[Fungal skin infection]] ([[tinea corporis]]) | *[[Mycosis|Fungal skin infection]] ([[tinea corporis]]) | ||
*[[Toxic erythema of chemotherapy]] | *[[Erythema toxicum|Toxic erythema]] of [[chemotherapy]] | ||
*Drug eruption | *[[Drug eruption]] | ||
==References== | ==References== | ||
Revision as of 14:23, 3 July 2017
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The differential diagnosis of GvHD is broad given the complexity of post-transplant patients.
Differential Diagnosis
The differential diagnosis for GvHD can be categorized into the specific organs involved. When a post-transplant patient develops liver, GI, or skin symptoms, there are numerous possibilities regarding the etiology, as post-transplant patients are immunocompromised and at risk for infections. The clinical manifestations of infection in the liver, GI tract, and skin can mimic symptoms of GvHD.
For liver signs and symptoms, differential diagnosis includes:
- CMV hepatitis[1]
- Sinusoidal obstruction syndrome (hepatic veno-occlusive disease)
- Viral hepatitis[1]
- Cholelithiasis
- Choledocholithiasis
For gastrointestinal signs and symptoms, differential diagnosis includes:
- Typhilitis (neutropenic enterocolitis)
- Clostridium difficile colitis
- Viral gastroenteritis[1]
- Ischemic colitis
For skin signs and symptoms, differential diagnosis includes:
- Varicella zoster (shingles)
- Bacterial cellulitis
- Fungal skin infection (tinea corporis)
- Toxic erythema of chemotherapy
- Drug eruption
References
- ↑ 1.0 1.1 1.2 McDonald GB (2016). "How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver". Blood. 127 (12): 1544–50. doi:10.1182/blood-2015-10-612747. PMC 4807421. PMID 26729898.