Filariasis pathophysiology: Difference between revisions
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* Another mosquito ingests the microfiliae. | * Another mosquito ingests the microfiliae. | ||
* The microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the [[midgut]] to reach the thoracic muscles | * The microfilariae lose their sheaths and work their way through the wall of the proventriculus and cardiac portion of the [[midgut]] to reach the thoracic muscles | ||
* Microfiliae | * Microfiliae mature inside the mosquito till third stage larvae. | ||
* In another bite to a host skin the mosquito introduces the larvae onto the skin. | * In another bite to a host skin the mosquito introduces the larvae onto the skin. | ||
| rowspan="2" |[[Image:W bancrofti LifeCycle.gif|350 px|center]] | | rowspan="2" |[[Image:W bancrofti LifeCycle.gif|350 px|center]] | ||
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* Another fly ingests the microfiliae. | * Another fly ingests the microfiliae. | ||
* After ingestion, the microfilariae lose their sheaths and migrate from the fly's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]]. | * After ingestion, the microfilariae lose their sheaths and migrate from the fly's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]]. | ||
* Microfiliae | * Microfiliae mature inside the fly till third stage larvae. | ||
* The third-stage infective larvae migrate to the fly's proboscis and in another bite the cycle restarts. | * The third-stage infective larvae migrate to the fly's proboscis and in another bite the cycle restarts. | ||
| rowspan="4" |[[Image:L loa LifeCycle.gif|350 px|center]] | | rowspan="4" |[[Image:L loa LifeCycle.gif|350 px|center]] | ||
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* Another midge ingests microfilariae during a [[blood]] meal. | * Another midge ingests microfilariae during a [[blood]] meal. | ||
* After [[ingestion]], the microfilariae migrate from the midge's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]]. | * After [[ingestion]], the microfilariae migrate from the midge's [[midgut]] through the [[hemocoel]] to the thoracic muscles of the [[arthropod]]. | ||
* Microfiliae | * Microfiliae mature inside the midge till third stage larvae. | ||
* The third-stage infective larvae migrate to the midge's proboscis and in another bite the cycle restarts. | * The third-stage infective larvae migrate to the midge's proboscis and in another bite the cycle restarts. | ||
|[[Image:M perstans LifeCycle.gif|350 px|center]] | |[[Image:M perstans LifeCycle.gif|350 px|center]] |
Revision as of 15:28, 27 June 2017
Filariasis Microchapters |
Diagnosis |
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Filariasis pathophysiology On the Web |
American Roentgen Ray Society Images of Filariasis pathophysiology |
Risk calculators and risk factors for Filariasis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2] Ahmed Elsaiey, MBBCH [3]
Overview
Pathophysiology
Generally, filariasis infection occurs when a larva carrying mosquito bites individual skin introducing these larvae onto the skin. The larvae then enter the patient blood through the skin wound and spread to the different sites of infection either lymphatic vessels, subcutaneous tissues or the serous cavities. At those different sites, The larvae tend to mature in a six to twelve months process to be adult filariae which can live up to fifteen years. Reproduction takes place between the male and female adult worms producing microfilariae which are premature organisms with sheath that circulate the blood in case they are settled in the lymphatic vessels. During another blood meal, the mosquito takes up the microfilariae then those microfilariae lose their sheath within two weeks to be larvae that enter the human body when the human is bitten by a mosquito and the cycle restarts again.[1]
Pathogenesis
- Factors affecting the pathogenesis of filariasis:
- Immune response of the patient
- Insect bite extent
- The number of filarial and bacterial infection
- The accumulation of the worm antigen in the lymphatic vessels.
Life cycle of filariasis nematodes
Type of filariasis | Causative nematode | Vectors | Life cycle | Illustrative image | Distinctive features |
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Lymphatic filariasis | Wuchereria bancrofti |
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Brugia timori and Brugia malayi |
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Subcutaneous filariasis | Loa loa filaria |
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| |
Mansonella streptocerca |
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Mansonella ozzardi |
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Onchocerca volvulus |
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Serous cavity filariasis | Mansonella perstans |
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References
- ↑ Chandy A, Thakur AS, Singh MP, Manigauha A (2011). "A review of neglected tropical diseases: filariasis". Asian Pac J Trop Med. 4 (7): 581–6. doi:10.1016/S1995-7645(11)60150-8. PMID 21803313.