Systemic lupus erythematosus risk factors: Difference between revisions
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==Overview== | ==Overview== | ||
The most potent risk factor in the development of systemic lupus erythematosus is sex. Other risk factors include [[HLA]] genetic mutations, being African Americans, Asians, and non-Causcasian, and infections. | The most potent risk factor in the development of systemic lupus erythematosus is sex.<ref name="pmid16896282">{{cite journal |vauthors=Grimaldi CM |title=Sex and systemic lupus erythematosus: the role of the sex hormones estrogen and prolactin on the regulation of autoreactive B cells |journal=Curr Opin Rheumatol |volume=18 |issue=5 |pages=456–61 |year=2006 |pmid=16896282 |doi=10.1097/01.bor.0000240354.37927.dd |url=}}</ref> Other risk factors include [[HLA]] genetic mutations, being African Americans, Asians, and non-Causcasian, and infections. | ||
==Risk Factors== | ==Risk Factors== | ||
The underlying cause of this autoimmune disease is not clear. Clinical data shows that the onset of systemic lupus erythematosus is associated with the following factors: | The underlying cause of this autoimmune disease is not clear. Clinical data shows that the onset of systemic lupus erythematosus is associated with the following factors: | ||
* Female: SLE affects nine times as many women as men. | * Female: SLE affects nine times as many women as men.<ref name="urlNIH Fact Sheets - Lupus">{{cite web |url=https://report.nih.gov/NIHfactsheets/ViewFactSheet.aspx?csid=47 |title=NIH Fact Sheets - Lupus |format= |work= |accessdate=}}</ref> | ||
* Younger than 50 | * Younger than 50 | ||
* Race: African Americans, Asians, and non-Causcasian race are affected more often than people from other races | * Race: African Americans, Asians, and non-Causcasian race are affected more often than people from other races.<ref name="pmid7575721">{{cite journal |vauthors=McCarty DJ, Manzi S, Medsger TA, Ramsey-Goldman R, LaPorte RE, Kwoh CK |title=Incidence of systemic lupus erythematosus. Race and gender differences |journal=Arthritis Rheum. |volume=38 |issue=9 |pages=1260–70 |year=1995 |pmid=7575721 |doi= |url=}}</ref> | ||
* Drugs | * Drugs | ||
** [[chlorpromazine]] | ** [[chlorpromazine]] | ||
| Line 24: | Line 24: | ||
* Infections can stimulates some antigen specific cells and lead to SLE disease: | * Infections can stimulates some antigen specific cells and lead to SLE disease: | ||
** [[Epstein Barr virus|Epstein-Barr virus (EBV)]]: may induce anti-DNA antibodies or even lupus-like symptoms. It is associated with higher risk of SLE and also triggering the active course of disease in children | ** [[Epstein Barr virus|Epstein-Barr virus (EBV)]]: may induce anti-DNA antibodies or even lupus-like symptoms. It is associated with higher risk of SLE and also triggering the active course of disease in children<ref name="pmid23342374">{{cite journal |vauthors=Lossius A, Johansen JN, Torkildsen Ø, Vartdal F, Holmøy T |title=Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation |journal=Viruses |volume=4 |issue=12 |pages=3701–30 |year=2012 |pmid=23342374 |pmc=3528287 |doi= |url=}}</ref> | ||
** [[Trypanosomiasis]] or [[mycobacterial]] infections may have the same effect as EBV | ** [[Trypanosomiasis]] or [[mycobacterial]] infections may have the same effect as EBV | ||
* [[Ultraviolet]] (UV) light | * [[Ultraviolet]] (UV) light | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]
Overview
The most potent risk factor in the development of systemic lupus erythematosus is sex.[1] Other risk factors include HLA genetic mutations, being African Americans, Asians, and non-Causcasian, and infections.
Risk Factors
The underlying cause of this autoimmune disease is not clear. Clinical data shows that the onset of systemic lupus erythematosus is associated with the following factors:
- Female: SLE affects nine times as many women as men.[2]
- Younger than 50
- Race: African Americans, Asians, and non-Causcasian race are affected more often than people from other races.[3]
- Drugs
- People with relatives who suffer from SLE, rheumatoid arthritis or thrombotic thrombocytopenic purpura are at a slightly higher risk than the general population[4]
- Infections can stimulates some antigen specific cells and lead to SLE disease:
- Epstein-Barr virus (EBV): may induce anti-DNA antibodies or even lupus-like symptoms. It is associated with higher risk of SLE and also triggering the active course of disease in children[5]
- Trypanosomiasis or mycobacterial infections may have the same effect as EBV
- Ultraviolet (UV) light
- Cigarette smoking [6]
- Crystalline silica exposure in work environment (e.g. cleaning powders, soil, pottery materials, cement etc.) [7]
- Drug allergy [8]
- Caring a pet (especially pet dog)
- Moderate alcohol drinking might be protective for SLE [9]
References
- ↑ Grimaldi CM (2006). "Sex and systemic lupus erythematosus: the role of the sex hormones estrogen and prolactin on the regulation of autoreactive B cells". Curr Opin Rheumatol. 18 (5): 456–61. doi:10.1097/01.bor.0000240354.37927.dd. PMID 16896282.
- ↑ "NIH Fact Sheets - Lupus".
- ↑ McCarty DJ, Manzi S, Medsger TA, Ramsey-Goldman R, LaPorte RE, Kwoh CK (1995). "Incidence of systemic lupus erythematosus. Race and gender differences". Arthritis Rheum. 38 (9): 1260–70. PMID 7575721.
- ↑ DiGeronimo, Theresa. New Hope for People with Lupus. Prima Publishing. 2002.
- ↑ Lossius A, Johansen JN, Torkildsen Ø, Vartdal F, Holmøy T (2012). "Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation". Viruses. 4 (12): 3701–30. PMC 3528287. PMID 23342374.
- ↑ Ghaussy NO, Sibbitt WL, Qualls CR (2001). "Cigarette smoking, alcohol consumption, and the risk of systemic lupus erythematosus: a case-control study". J. Rheumatol. 28 (11): 2449–53. PMID 11708417.
- ↑ Parks CG, Cooper GS, Nylander-French LA, Sanderson WT, Dement JM, Cohen PL, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Hoppin JA, Savitz DA (2002). "Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United States". Arthritis Rheum. 46 (7): 1840–50. doi:10.1002/art.10368. PMID 12124868.
- ↑ Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS (2002). "Risk factors for development of systemic lupus erythematosus: allergies, infections, and family history". J Clin Epidemiol. 55 (10): 982–9. PMID 12464374.
- ↑ Wang J, Pan HF, Ye DQ, Su H, Li XP (2008). "Moderate alcohol drinking might be protective for systemic lupus erythematosus: a systematic review and meta-analysis". Clin. Rheumatol. 27 (12): 1557–63. doi:10.1007/s10067-008-1004-z. PMID 18795396.