Growth hormone deficiency history and symptoms: Difference between revisions
Jump to navigation
Jump to search
Usama Talib (talk | contribs) No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3]. | |||
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most | |||
==History and Symptoms== | ==History and Symptoms== | ||
Common symptoms of growth hormone deficiency include: | |||
Common symptoms of | |||
=== | ==== Neonatal symptoms 31 28 ==== | ||
Less | * Higher frequency of perinatal asphyxia | ||
*[ | * Neonatal morbidity may include hypoglycemia and prolonged jaundice especially if combined with adrenocorticotropic hormone deficiency. | ||
*[ | * Cryptorchidism and hypoplasia of the scrotum | ||
*[ | * Growth failure can occur during the first months of life but may not be obvious until 6 to 12 months of age. | ||
* Bone age and height age are delayed but similar to each other. | |||
==== Childhood symptoms ==== | |||
* The single most important clinical manifestation of GHD is growth failure. | |||
* The growth failure may not be manifested until late infancy. | |||
* Children with acquired GHD present with infantile or doll-like fat distribution pattern, immature face with underdeveloped nasal bridge and frontal bossing. The voice is infantile, and hair growth is sparse and thin. | |||
* Delayed muscular development, so that gross motor milestones such as standing, walking, and jumping may be delayed. | |||
'''Adult symptoms''' | |||
* Patients with childhood-onset GH deficiency have more severe clinical manifestations than those who develop it as adults [6]. | |||
* Lean body mass is increased in adults who are deficient in GH and not replaced compared with those who have normal GH secretion [7-10]. | |||
* Fractures of the lumbar spine is somewhat lower in patients with adult-onset GH deficiency | |||
* The degree of osteopenia appears to correlate directly with the degree of GH deficiency 11 | |||
* Less energetic than normal people of the same age [14-16] | |||
'''Cardiovascular risk factors''' | |||
* Dyslipidemia [17-19] | |||
* Increased inflammatory markers [20] | |||
* Increase in biochemical markers of endothelial dysfunction [21] | |||
* High coronary calcium scores (a marker of subclinical atherosclerosis) [22 | |||
==References== | ==References== | ||
Revision as of 13:57, 9 August 2017
|
Growth hormone deficiency Microchapters |
|
Differentiating Growth hormone deficiency from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Growth hormone deficiency history and symptoms On the Web |
|
American Roentgen Ray Society Images of Growth hormone deficiency history and symptoms |
|
Risk calculators and risk factors for Growth hormone deficiency history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
History and Symptoms
Common symptoms of growth hormone deficiency include:
Neonatal symptoms 31 28
- Higher frequency of perinatal asphyxia
- Neonatal morbidity may include hypoglycemia and prolonged jaundice especially if combined with adrenocorticotropic hormone deficiency.
- Cryptorchidism and hypoplasia of the scrotum
- Growth failure can occur during the first months of life but may not be obvious until 6 to 12 months of age.
- Bone age and height age are delayed but similar to each other.
Childhood symptoms
- The single most important clinical manifestation of GHD is growth failure.
- The growth failure may not be manifested until late infancy.
- Children with acquired GHD present with infantile or doll-like fat distribution pattern, immature face with underdeveloped nasal bridge and frontal bossing. The voice is infantile, and hair growth is sparse and thin.
- Delayed muscular development, so that gross motor milestones such as standing, walking, and jumping may be delayed.
Adult symptoms
- Patients with childhood-onset GH deficiency have more severe clinical manifestations than those who develop it as adults [6].
- Lean body mass is increased in adults who are deficient in GH and not replaced compared with those who have normal GH secretion [7-10].
- Fractures of the lumbar spine is somewhat lower in patients with adult-onset GH deficiency
- The degree of osteopenia appears to correlate directly with the degree of GH deficiency 11
- Less energetic than normal people of the same age [14-16]
Cardiovascular risk factors
- Dyslipidemia [17-19]
- Increased inflammatory markers [20]
- Increase in biochemical markers of endothelial dysfunction [21]
- High coronary calcium scores (a marker of subclinical atherosclerosis) [22