Insulinoma surgery

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

Surgery is the mainstay of treatment for insulinoma. The feasibility of surgery depends on the stage of insulinoma at diagnosis.

Surgery

Surgery is the mainstay of treatment for benign and resectable malignant insulinoma. The feasibility of surgery depends on the stage of insulinoma at diagnosis.

Benign Tumors

• Small well-encapsulated, solitary tumors:

• Surgical resection is treatment of choice (minimal invasive surgery)

• Enucleation
• Partial pancreatectomy
• Middle pancreatectomy

• Multiple, unencapsulated, >4 cm in diameter, and involves or is near the main pancreatic duct:

• Radical resection

Malignant Tumors

• Resectable tumors:

• Aggressive surgical resection, including extended pancreatic resection, liver resection, and/or liver transplantation
• Post-surgical chemoembolization or radiofrequency ablation of tumors to control hypoglycemia

• Unresectable tumors

• Octreotide administration
• Continous glucose monitoring
• Radiofrequecy ablation
• Embolization
• Intra-arterial chemotherapy

Overview

Surgery is the mainstay of treatment for insulinoma

Surgery

• Surgical intervention is not recommended for the management of [disease name].

OR

• Surgery is not the first-line treatment option for patients with [disease name]. Surgery is usually reserved for patients with either:
  • [Indication 1]
  • [Indication 2]
  • [Indication 3]
• The mainstay of treatment for [disease name] is medical therapy. Surgery is usually reserved for patients with either:
  • [Indication 1]
  • [Indication 2]
  • [Indication 3]
• The feasibility of surgery depends on the stage of [malignancy] at diagnosis.

OR

• Surgery is the mainstay of treatment for [disease or malignancy].

References

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