Insulinoma other imaging findings: Difference between revisions
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==Other Imaging Findings== | ==Other Imaging Findings== | ||
===Positron Emission Tomography=== | ===[[Positron emission tomography|Positron Emission Tomography]]=== | ||
*Positron emitting radioisotopes of Gallium such as 68 Gallium-DOTATAC, 68 Gallium-DOTATATE, and 68 Gallium-DOTANAC can be used to detect the uptakes in areas of increased somatostatin receptors. The sensitivity is increased when it is coupled with CT scan although it is not approved for routine use in the United States. It is mainly used for investigation purpose.<ref name="pmid25493261">{{cite journal |vauthors=Sadowski SM, Neychev V, Cottle-Delisle C, Merkel R, Yang LA, Quezado MM, Chang R, Kebebew E |title=Detection of insulinoma using (68)Gallium-DOTATATE PET/CT: a case report |journal=Gland Surg |volume=3 |issue=4 |pages=E1–5 |year=2014 |pmid=25493261 |pmc=4244512 |doi=10.3978/j.issn.2227-684X.2014.10.02 |url=}}</ref><ref name="pmid17401086">{{cite journal |vauthors=Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, Kovacs P, Von Guggenberg E, Bale R, Virgolini IJ |title=68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT |journal=J. Nucl. Med. |volume=48 |issue=4 |pages=508–18 |year=2007 |pmid=17401086 |doi= |url=}}</ref><ref name="pmid22984220">{{cite journal |vauthors=Haug AR, Cindea-Drimus R, Auernhammer CJ, Reincke M, Wängler B, Uebleis C, Schmidt GP, Göke B, Bartenstein P, Hacker M |title=The role of 68Ga-DOTATATE PET/CT in suspected neuroendocrine tumors |journal=J. Nucl. Med. |volume=53 |issue=11 |pages=1686–92 |year=2012 |pmid=22984220 |doi=10.2967/jnumed.111.101675 |url=}}</ref> | *[[Positron]] emitting [[radioisotopes]] of [[Gallium]] such as 68 [[Gallium]]-DOTATAC, 68 [[Gallium]]-DOTATATE, and 68 [[Gallium]]-DOTANAC can be used to detect the uptakes in areas of increased somatostatin receptors. The [[Sensitivity (tests)|sensitivity]] is increased when it is coupled with [[CT]] scan although it is not approved for routine use in the United States. It is mainly used for investigation purpose.<ref name="pmid25493261">{{cite journal |vauthors=Sadowski SM, Neychev V, Cottle-Delisle C, Merkel R, Yang LA, Quezado MM, Chang R, Kebebew E |title=Detection of insulinoma using (68)Gallium-DOTATATE PET/CT: a case report |journal=Gland Surg |volume=3 |issue=4 |pages=E1–5 |year=2014 |pmid=25493261 |pmc=4244512 |doi=10.3978/j.issn.2227-684X.2014.10.02 |url=}}</ref><ref name="pmid17401086">{{cite journal |vauthors=Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, Kovacs P, Von Guggenberg E, Bale R, Virgolini IJ |title=68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT |journal=J. Nucl. Med. |volume=48 |issue=4 |pages=508–18 |year=2007 |pmid=17401086 |doi= |url=}}</ref><ref name="pmid22984220">{{cite journal |vauthors=Haug AR, Cindea-Drimus R, Auernhammer CJ, Reincke M, Wängler B, Uebleis C, Schmidt GP, Göke B, Bartenstein P, Hacker M |title=The role of 68Ga-DOTATATE PET/CT in suspected neuroendocrine tumors |journal=J. Nucl. Med. |volume=53 |issue=11 |pages=1686–92 |year=2012 |pmid=22984220 |doi=10.2967/jnumed.111.101675 |url=}}</ref> | ||
*Positron Emission Tomography(PET) may be helpful in the diagnosis of insulinoma. Findings on a PET scan suggestive of insulinoma include: | *Positron Emission Tomography(PET) may be helpful in the diagnosis of [[insulinoma]]. Findings on a [[PET scan]] suggestive of insulinoma include: | ||
**Increased uptake in the affected part of the pancreas. | **Increased uptake in the affected part of the pancreas. | ||
**Metastasis can also be detected in the same way | **[[Metastasis]] can also be detected in the same way | ||
===Somatostatin receptor scintigraphy=== | ===Somatostatin receptor scintigraphy=== | ||
| Line 22: | Line 22: | ||
*Somatostatin receptor scintigraphy(SRS) may be helpful in the diagnosis of pancreatic neuroendocrine tumors including insulinomas. As many insulinomas does not express [[somatostatin]] subtype 2 receptors, it is less sensitive(50-60%).<ref name="pmid8944566">{{cite journal| author=Zimmer T, Stölzel U, Bäder M, Koppenhagen K, Hamm B, Buhr H et al.| title=Endoscopic ultrasonography and somatostatin receptor scintigraphy in the preoperative localisation of insulinomas and gastrinomas. | journal=Gut | year= 1996 | volume= 39 | issue= 4 | pages= 562-8 | pmid=8944566 | doi= | pmc=1383270 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8944566 }} </ref><ref name="pmid9854595">{{cite journal| author=Proye C, Malvaux P, Pattou F, Filoche B, Godchaux JM, Maunoury V et al.| title=Noninvasive imaging of insulinomas and gastrinomas with endoscopic ultrasonography and somatostatin receptor scintigraphy. | journal=Surgery | year= 1998 | volume= 124 | issue= 6 | pages= 1134-43; discussion 1143-4 | pmid=9854595 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9854595 }} </ref> <ref name="McAuleyDelaney2005">{{cite journal|last1=McAuley|first1=G.|last2=Delaney|first2=H.|last3=Colville|first3=J.|last4=Lyburn|first4=I.|last5=Worsley|first5=D.|last6=Govender|first6=P.|last7=Torreggiani|first7=W.C.|title=Multimodality preoperative imaging of pancreatic insulinomas|journal=Clinical Radiology|volume=60|issue=10|year=2005|pages=1039–1050|issn=00099260|doi=10.1016/j.crad.2005.06.005}}</ref><ref name="pmid7513113">{{cite journal| author=Behr T, Becker W, Koch W, Grebmeier J, Wolf F| title=[Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. | journal=Z Gastroenterol | year= 1994 | volume= 32 | issue= 2 | pages= 100-4 | pmid=7513113 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7513113 }} </ref><ref name="pmid9825476">{{cite journal |vauthors=Jensen RT, Gibril F, Termanini B |title=Definition of the role of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumor localization |journal=Yale J Biol Med |volume=70 |issue=5-6 |pages=481–500 |year=1997 |pmid=9825476 |pmc=2589266 |doi= |url=}}</ref> | *Somatostatin receptor scintigraphy(SRS) may be helpful in the diagnosis of pancreatic neuroendocrine tumors including insulinomas. As many insulinomas does not express [[somatostatin]] subtype 2 receptors, it is less sensitive(50-60%).<ref name="pmid8944566">{{cite journal| author=Zimmer T, Stölzel U, Bäder M, Koppenhagen K, Hamm B, Buhr H et al.| title=Endoscopic ultrasonography and somatostatin receptor scintigraphy in the preoperative localisation of insulinomas and gastrinomas. | journal=Gut | year= 1996 | volume= 39 | issue= 4 | pages= 562-8 | pmid=8944566 | doi= | pmc=1383270 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8944566 }} </ref><ref name="pmid9854595">{{cite journal| author=Proye C, Malvaux P, Pattou F, Filoche B, Godchaux JM, Maunoury V et al.| title=Noninvasive imaging of insulinomas and gastrinomas with endoscopic ultrasonography and somatostatin receptor scintigraphy. | journal=Surgery | year= 1998 | volume= 124 | issue= 6 | pages= 1134-43; discussion 1143-4 | pmid=9854595 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9854595 }} </ref> <ref name="McAuleyDelaney2005">{{cite journal|last1=McAuley|first1=G.|last2=Delaney|first2=H.|last3=Colville|first3=J.|last4=Lyburn|first4=I.|last5=Worsley|first5=D.|last6=Govender|first6=P.|last7=Torreggiani|first7=W.C.|title=Multimodality preoperative imaging of pancreatic insulinomas|journal=Clinical Radiology|volume=60|issue=10|year=2005|pages=1039–1050|issn=00099260|doi=10.1016/j.crad.2005.06.005}}</ref><ref name="pmid7513113">{{cite journal| author=Behr T, Becker W, Koch W, Grebmeier J, Wolf F| title=[Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. | journal=Z Gastroenterol | year= 1994 | volume= 32 | issue= 2 | pages= 100-4 | pmid=7513113 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7513113 }} </ref><ref name="pmid9825476">{{cite journal |vauthors=Jensen RT, Gibril F, Termanini B |title=Definition of the role of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumor localization |journal=Yale J Biol Med |volume=70 |issue=5-6 |pages=481–500 |year=1997 |pmid=9825476 |pmc=2589266 |doi= |url=}}</ref> | ||
Findings on an SRS suggestive of insulinoma include: | Findings on an SRS suggestive of insulinoma include: | ||
*Increased uptake of | *Increased uptake of pentetreotide (synthetic somatostatin analogue) | ||
*Increased uptake in sites of metastasis, commonly in hepatic involvement | *Increased uptake in sites of metastasis, commonly in hepatic involvement | ||
Revision as of 20:41, 31 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Amandeep Singh M.D.[2]
Overview
There are no other imaging findings associated with [disease name].
OR
[Imaging modality] may be helpful in the diagnosis of [disease name]. Findings on an [imaging modality] suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
Other Imaging Findings
Positron Emission Tomography
- Positron emitting radioisotopes of Gallium such as 68 Gallium-DOTATAC, 68 Gallium-DOTATATE, and 68 Gallium-DOTANAC can be used to detect the uptakes in areas of increased somatostatin receptors. The sensitivity is increased when it is coupled with CT scan although it is not approved for routine use in the United States. It is mainly used for investigation purpose.[1][2][3]
- Positron Emission Tomography(PET) may be helpful in the diagnosis of insulinoma. Findings on a PET scan suggestive of insulinoma include:
- Increased uptake in the affected part of the pancreas.
- Metastasis can also be detected in the same way
Somatostatin receptor scintigraphy
- Somatostatin receptor scintigraphy(SRS) may be helpful in the diagnosis of pancreatic neuroendocrine tumors including insulinomas. As many insulinomas does not express somatostatin subtype 2 receptors, it is less sensitive(50-60%).[4][5] [6][7][8]
Findings on an SRS suggestive of insulinoma include:
- Increased uptake of pentetreotide (synthetic somatostatin analogue)
- Increased uptake in sites of metastasis, commonly in hepatic involvement
References
- ↑ Sadowski SM, Neychev V, Cottle-Delisle C, Merkel R, Yang LA, Quezado MM, Chang R, Kebebew E (2014). "Detection of insulinoma using (68)Gallium-DOTATATE PET/CT: a case report". Gland Surg. 3 (4): E1–5. doi:10.3978/j.issn.2227-684X.2014.10.02. PMC 4244512. PMID 25493261.
- ↑ Gabriel M, Decristoforo C, Kendler D, Dobrozemsky G, Heute D, Uprimny C, Kovacs P, Von Guggenberg E, Bale R, Virgolini IJ (2007). "68Ga-DOTA-Tyr3-octreotide PET in neuroendocrine tumors: comparison with somatostatin receptor scintigraphy and CT". J. Nucl. Med. 48 (4): 508–18. PMID 17401086.
- ↑ Haug AR, Cindea-Drimus R, Auernhammer CJ, Reincke M, Wängler B, Uebleis C, Schmidt GP, Göke B, Bartenstein P, Hacker M (2012). "The role of 68Ga-DOTATATE PET/CT in suspected neuroendocrine tumors". J. Nucl. Med. 53 (11): 1686–92. doi:10.2967/jnumed.111.101675. PMID 22984220.
- ↑ Zimmer T, Stölzel U, Bäder M, Koppenhagen K, Hamm B, Buhr H; et al. (1996). "Endoscopic ultrasonography and somatostatin receptor scintigraphy in the preoperative localisation of insulinomas and gastrinomas". Gut. 39 (4): 562–8. PMC 1383270. PMID 8944566.
- ↑ Proye C, Malvaux P, Pattou F, Filoche B, Godchaux JM, Maunoury V; et al. (1998). "Noninvasive imaging of insulinomas and gastrinomas with endoscopic ultrasonography and somatostatin receptor scintigraphy". Surgery. 124 (6): 1134–43, discussion 1143-4. PMID 9854595.
- ↑ McAuley, G.; Delaney, H.; Colville, J.; Lyburn, I.; Worsley, D.; Govender, P.; Torreggiani, W.C. (2005). "Multimodality preoperative imaging of pancreatic insulinomas". Clinical Radiology. 60 (10): 1039–1050. doi:10.1016/j.crad.2005.06.005. ISSN 0009-9260.
- ↑ Behr T, Becker W, Koch W, Grebmeier J, Wolf F (1994). "[Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]". Z Gastroenterol. 32 (2): 100–4. PMID 7513113.
- ↑ Jensen RT, Gibril F, Termanini B (1997). "Definition of the role of somatostatin receptor scintigraphy in gastrointestinal neuroendocrine tumor localization". Yale J Biol Med. 70 (5–6): 481–500. PMC 2589266. PMID 9825476.