Delayed puberty differential diagnosis: Difference between revisions
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==Differentiating Delayed puberty from other diseases== | ==Differentiating Delayed puberty from other diseases== | ||
* Delayed [[puberty]] must be differentiated from other [[diseases]] that cause latency in [[secondary sexual characteristics]] development, such as [[constitutional delay of puberty]], [[hypopituitarism]], and [[chromosomal abnormalities]]. [[Chromosomal abnormalities]] are [[Turner's syndrome]], [[Klinefelter's syndrome]], and [[Noonan's syndrome]]. | * Delayed [[puberty]] must be differentiated from other [[diseases]] that cause latency in [[secondary sexual characteristics]] development, such as [[constitutional delay of puberty]], [[hypopituitarism]], and [[chromosomal abnormalities]]. [[Chromosomal abnormalities]] are [[Turner's syndrome]], [[Klinefelter's syndrome]], and [[Noonan's syndrome]].<ref name="pmid10414639">{{cite journal |vauthors=Blondell RD, Foster MB, Dave KC |title=Disorders of puberty |journal=Am Fam Physician |volume=60 |issue=1 |pages=209–18, 223–4 |year=1999 |pmid=10414639 |doi= |url=}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
! colspan="2" rowspan="2" |Diseases | ! colspan="2" rowspan="2" |Diseases | ||
Revision as of 20:32, 5 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]
Overview
Delayed puberty must be differentiated from other diseases that cause latency in secondary sexual characteristics development, such as constitutional delay of puberty, hypopituitarism, and chromosomal abnormalities. Chromosomal abnormalities are Turner's syndrome, Klinefelter's syndrome, and Noonan's syndrome.
Differentiating Delayed puberty from other diseases
- Delayed puberty must be differentiated from other diseases that cause latency in secondary sexual characteristics development, such as constitutional delay of puberty, hypopituitarism, and chromosomal abnormalities. Chromosomal abnormalities are Turner's syndrome, Klinefelter's syndrome, and Noonan's syndrome.[1]
| Diseases | Laboratory Findings | Physical examinations | Other Findings | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GnRH | LH | FSH | Estradiol | Testosterone | Lack of secondary sexual characteristics | Amenorrhea | Webbed neck | Final height | |||
| Delayed puberty | Primary hypogonadism | ↑ | ↑ | ↑ | ↓ | ↓ | + | + | - | ↓ | - |
| Secondary hypogonadism | ↓ | ↓ | ↓ | ↓ | ↓ | + | + | - | ↓ | - | |
| Constitutional delay of puberty | Nl | Nl | Nl | Nl | Nl | + | + | - | Nl | Normal puberty, finally | |
| Hypopituitarism | ↑ | ↓ | ↓ | ↓ | ↓ | + | + | - | ↓ | - | |
| Turner's syndrome | ↓ | ↑ | ↑ | ↓ | - | + | + | + | ↓ | Bicuspid aortic valve | |
| Klinefelter's syndrome | ↓ | ↑ | ↑ | - | ↓ | + | - | - | Nl | Testicular dysgenesis | |
| Noonan's syndrome | ↓ | ↑ | ↑ | - | ↓ | + | - | + | Nl | Mitral valve prolapse | |