Cretinism natural history, complications and prognosis: Difference between revisions
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===Prognosis=== | ===Prognosis=== | ||
*Prognosis is generally excellent with the appropriate treatment with levothyroxine. | *Prognosis is generally excellent with the appropriate treatment with levothyroxine.<ref name="pmid20537182">{{cite journal| author=Rastogi MV, LaFranchi SH| title=Congenital hypothyroidism. | journal=Orphanet J Rare Dis | year= 2010 | volume= 5 | issue= | pages= 17 | pmid=20537182 | doi=10.1186/1750-1172-5-17 | pmc=2903524 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20537182 }} </ref> | ||
==References== | ==References== | ||
Revision as of 14:27, 8 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of cretinism usually develop in the first months after birth, and start with symptoms such as jaundice, large fontanelles, and umbilical hernia.
- If left untreated, patients with cretinism may progress to develop mental retardation and neurological manifestations like ataxia and poor motor coordination.[1]
Complications
- Common complications of cretinism include:[2]
- Mental retardation
- Growth retardation
- Heart problems
Prognosis
- Prognosis is generally excellent with the appropriate treatment with levothyroxine.[3]
References
- ↑ Büyükgebiz A (2003). "Congenital hypothyroidism clinical aspects and late consequences". Pediatr Endocrinol Rev. 1 Suppl 2: 185–90, discussion 190. PMID 16444157.
- ↑ Pearce EN, Lazarus JH, Moreno-Reyes R, Zimmermann MB (2016). "Consequences of iodine deficiency and excess in pregnant women: an overview of current knowns and unknowns". Am J Clin Nutr. 104 Suppl 3: 918S–23S. doi:10.3945/ajcn.115.110429. PMC 5004501. PMID 27534632.
- ↑ Rastogi MV, LaFranchi SH (2010). "Congenital hypothyroidism". Orphanet J Rare Dis. 5: 17. doi:10.1186/1750-1172-5-17. PMC 2903524. PMID 20537182.