Delayed puberty secondary prevention: Difference between revisions
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* It seems that delayed [[puberty]] can lead to lower [[Bone mineral density|bone mineral density (BMD)]] in adulthood.<ref name="FinkelsteinNeer1992">{{cite journal|last1=Finkelstein|first1=Joel S.|last2=Neer|first2=Robert M.|last3=Biller|first3=Beverly M.K.|last4=Crawford|first4=John D.|last5=Klibanski|first5=Anne|title=Osteopenia in Men with a History of Delayed Puberty|journal=New England Journal of Medicine|volume=326|issue=9|year=1992|pages=600–604|issn=0028-4793|doi=10.1056/NEJM199202273260904}}</ref> | * It seems that delayed [[puberty]] can lead to lower [[Bone mineral density|bone mineral density (BMD)]] in adulthood.<ref name="FinkelsteinNeer1992">{{cite journal|last1=Finkelstein|first1=Joel S.|last2=Neer|first2=Robert M.|last3=Biller|first3=Beverly M.K.|last4=Crawford|first4=John D.|last5=Klibanski|first5=Anne|title=Osteopenia in Men with a History of Delayed Puberty|journal=New England Journal of Medicine|volume=326|issue=9|year=1992|pages=600–604|issn=0028-4793|doi=10.1056/NEJM199202273260904}}</ref> | ||
* Since the lower [[Bone mineral density|BMD]] is main risk factor for [[fracture]], therefore untreated delayed [[puberty]] leads to more [[fracture]] rate.<ref name="pmid2008183">{{cite journal |vauthors=Johnston CC, Slemenda CW, Melton LJ |title=Clinical use of bone densitometry |journal=N. Engl. J. Med. |volume=324 |issue=16 |pages=1105–9 |year=1991 |pmid=2008183 |doi=10.1056/NEJM199104183241606 |url=}}</ref> | * Since the lower [[Bone mineral density|BMD]] is the main risk factor for [[fracture]], therefore untreated delayed [[puberty]] leads to more [[fracture]] rate.<ref name="pmid2008183">{{cite journal |vauthors=Johnston CC, Slemenda CW, Melton LJ |title=Clinical use of bone densitometry |journal=N. Engl. J. Med. |volume=324 |issue=16 |pages=1105–9 |year=1991 |pmid=2008183 |doi=10.1056/NEJM199104183241606 |url=}}</ref> | ||
* Studies have shown that [[hormone]] therapy in boys, but not girls, with [[short stature]] and delayed [[puberty]] improves the adult height, proportionally.<ref name="pmid17717702">{{cite journal |vauthors=Zucchini S, Wasniewska M, Cisternino M, Salerno M, Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S |title=Adult height in children with short stature and idiopathic delayed puberty after different management |journal=Eur. J. Pediatr. |volume=167 |issue=6 |pages=677–81 |year=2008 |pmid=17717702 |doi=10.1007/s00431-007-0576-y |url=}}</ref> | * Studies have shown that [[hormone]] therapy in boys, but not girls, with [[short stature]] and delayed [[puberty]] improves the adult height, proportionally.<ref name="pmid17717702">{{cite journal |vauthors=Zucchini S, Wasniewska M, Cisternino M, Salerno M, Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S |title=Adult height in children with short stature and idiopathic delayed puberty after different management |journal=Eur. J. Pediatr. |volume=167 |issue=6 |pages=677–81 |year=2008 |pmid=17717702 |doi=10.1007/s00431-007-0576-y |url=}}</ref> | ||
* Timely initiation of [[hormonal therapy]] can also prevent any [[psychological]] problems in children with delayed [[puberty]].<ref name="pmid14671394">{{cite journal |vauthors=Pozo J, Argente J |title=Ascertainment and treatment of delayed puberty |journal=Horm. Res. |volume=60 Suppl 3 |issue= |pages=35–48 |year=2003 |pmid=14671394 |doi=74498 |url=}}</ref> | * Timely initiation of [[hormonal therapy]] can also prevent any [[psychological]] problems in children with delayed [[puberty]].<ref name="pmid14671394">{{cite journal |vauthors=Pozo J, Argente J |title=Ascertainment and treatment of delayed puberty |journal=Horm. Res. |volume=60 Suppl 3 |issue= |pages=35–48 |year=2003 |pmid=14671394 |doi=74498 |url=}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]
Overview
Effective measures for the secondary prevention of delayed puberty include timely clinical suspicion, suitable diagnosis, and hormone replacement therapy, in order to prevent osteoporosis and short adult height; and salpingo-oophorectomy in Turner syndrome, to prevent malignancy.
Secondary Prevention
- Effective measures for the secondary prevention of delayed puberty include:
- Timely clinical suspicion, suitable diagnosis, and hormone replacement therapy, in order to prevent osteoporosis and short adult height
- Salpingo-oophorectomy in Turner syndrome, to prevent malignancy
- It seems that delayed puberty can lead to lower bone mineral density (BMD) in adulthood.[1]
- Since the lower BMD is the main risk factor for fracture, therefore untreated delayed puberty leads to more fracture rate.[2]
- Studies have shown that hormone therapy in boys, but not girls, with short stature and delayed puberty improves the adult height, proportionally.[3]
- Timely initiation of hormonal therapy can also prevent any psychological problems in children with delayed puberty.[4]
References
- ↑ Finkelstein, Joel S.; Neer, Robert M.; Biller, Beverly M.K.; Crawford, John D.; Klibanski, Anne (1992). "Osteopenia in Men with a History of Delayed Puberty". New England Journal of Medicine. 326 (9): 600–604. doi:10.1056/NEJM199202273260904. ISSN 0028-4793.
- ↑ Johnston CC, Slemenda CW, Melton LJ (1991). "Clinical use of bone densitometry". N. Engl. J. Med. 324 (16): 1105–9. doi:10.1056/NEJM199104183241606. PMID 2008183.
- ↑ Zucchini S, Wasniewska M, Cisternino M, Salerno M, Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S (2008). "Adult height in children with short stature and idiopathic delayed puberty after different management". Eur. J. Pediatr. 167 (6): 677–81. doi:10.1007/s00431-007-0576-y. PMID 17717702.
- ↑ Pozo J, Argente J (2003). "Ascertainment and treatment of delayed puberty". Horm. Res. 60 Suppl 3: 35–48. doi:74498 Check
|doi=value (help). PMID 14671394.