Hirsutism future or investigational therapies: Difference between revisions
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==Future or Investigational Therapies== | ==Future or Investigational Therapies== | ||
A new topical antiandrogen Fluridil (2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl) phenyl]-3-(2,2,2-trifluoroacetylamino)ropanamide) has been developed for hyperandrogenic skin syndromes.[28] Based on these results, a study was conducted as an orientational three-month pilot study to evaluate the efficacy and safety of 2% fluridil gel in female patients with idiopathic hirsutism. The present clinical study has shown that a 2% fluridil gel is a safe and effective treatment method of hirsutism. However, this preparation is not available yet. Compared to systemic administration of antiandrogens, topical fluridil does not affect general health and sexual functions and, more importantly, does not decrease libido.<ref name=" | A new topical antiandrogen Fluridil (2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl) phenyl]-3-(2,2,2-trifluoroacetylamino)ropanamide) has been developed for hyperandrogenic skin syndromes.[28] Based on these results, a study was conducted as an orientational three-month pilot study to evaluate the efficacy and safety of 2% fluridil gel in female patients with idiopathic hirsutism. The present clinical study has shown that a 2% fluridil gel is a safe and effective treatment method of hirsutism. However, this preparation is not available yet. Compared to systemic administration of antiandrogens, topical fluridil does not affect general health and sexual functions and, more importantly, does not decrease libido.<ref name="pmid12174057">{{cite journal |vauthors=Sovak M, Seligson AL, Kucerova R, Bienova M, Hajduch M, Bucek M |title=Fluridil, a rationally designed topical agent for androgenetic alopecia: first clinical experience |journal=Dermatol Surg |volume=28 |issue=8 |pages=678–85 |year=2002 |pmid=12174057 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 17:14, 15 September 2017
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Future or Investigational Therapies
A new topical antiandrogen Fluridil (2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl) phenyl]-3-(2,2,2-trifluoroacetylamino)ropanamide) has been developed for hyperandrogenic skin syndromes.[28] Based on these results, a study was conducted as an orientational three-month pilot study to evaluate the efficacy and safety of 2% fluridil gel in female patients with idiopathic hirsutism. The present clinical study has shown that a 2% fluridil gel is a safe and effective treatment method of hirsutism. However, this preparation is not available yet. Compared to systemic administration of antiandrogens, topical fluridil does not affect general health and sexual functions and, more importantly, does not decrease libido.[1]