Hirsutism laboratory findings: Difference between revisions
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{{Hirsutism}} | {{Hirsutism}} | ||
{{CMG}};{{AE}} {{RHN}} | {{CMG}};{{AE}} {{RHN}}, {{AY}} | ||
==Overview== | ==Overview== | ||
Latest revision as of 13:43, 10 October 2017
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Hirsutism Microchapters |
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Risk calculators and risk factors for Hirsutism laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Rasam Hajiannasab M.D.[2], Ahmed Younes M.B.B.CH [3]
Overview
Laboratory tests that should be done in hirsutism include testosterone level, DHEAS, and 24-hour cortisol level.
Laboratory Finding
Testosterone
- Serum testosterone may be normal to increased in case of PCOS and CAH but would be definitely raised (>200 ng/ml) in case of malignant tumor of the adrenal or ovary.[1]
DHEAS
- Dehydroepiandrosterone sulfate (DHEAS): Raised DHEAS (>700 μg/dl) always indicates an adrenal cause, benign or malignant.
17-Hydroxyprogesterone
- 17 Hydroxy progesterone: Levels less than 200 ng/dl excludes CAH. Mildly increased levels between 300 and 1,000 ng/dl require an ACTH stimulation test. Cosyntropin (synthetic ACTH), 250 μg, is administered intravenously, and levels of 17-hydroxyprogesterone are measured before and one hour after the injection. Post-stimulation values (>1,000 ng/dl) constitute a positive test.[1]
24-hour urinary cortisol
- Twenty four hour urine free cortisol should be measured in women with signs and symptoms of Cushing's syndrome.
LH/FSH ratio
Serum TSH
- Serum TSH and Prolactin: Hypothyroidism and hyperprolactinemia can lead to hirsutism.[3]
References
- ↑ 1.0 1.1 Lin-Su K, Nimkarn S, New MI (2008). "Congenital adrenal hyperplasia in adolescents: diagnosis and management". Ann. N. Y. Acad. Sci. 1135: 95–8. doi:10.1196/annals.1429.021. PMID 18574213.
- ↑ Chang RJ, Katz SE (1999). "Diagnosis of polycystic ovary syndrome". Endocrinol. Metab. Clin. North Am. 28 (2): 397–408, vii. PMID 10352925.
- ↑ Schmidt JB, Lindmaier A, Spona J (1991). "[Hyperprolactinemia and hypophyseal hypothyroidism as cofactors in hirsutism and androgen-induced alopecia in women]". Hautarzt (in German). 42 (3): 168–72. PMID 1905280.