Irritable bowel syndrome pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
IBS is a functional disorder of visceral hypersensitivity which may lead to abdominal discomfort, diarrhea and constipation. <ref name="pmid12454866">{{cite journal |vauthors=Drossman DA, Camilleri M, Mayer EA, Whitehead WE |title=AGA technical review on irritable bowel syndrome |journal=Gastroenterology |volume=123 |issue=6 |pages=2108–31 |year=2002 |pmid=12454866 |doi=10.1053/gast.2002.37095 |url=}}</ref> <ref name="pmid12241674">{{cite journal |vauthors=Talley NJ, Spiller R |title=Irritable bowel syndrome: a little understood organic bowel disease? |journal=Lancet |volume=360 |issue=9332 |pages=555–64 |year=2002 |pmid=12241674 |doi=10.1016/S0140-6736(02)09712-X |url=}}</ref> <ref name="pmid24944467">{{cite journal |vauthors=Saha L |title=Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine |journal=World J. Gastroenterol. |volume=20 |issue=22 |pages=6759–73 |year=2014 |pmid=24944467 |pmc=4051916 |doi=10.3748/wjg.v20.i22.6759 |url=}}</ref> | IBS is a functional disorder of visceral hypersensitivity which may lead to abdominal discomfort, diarrhea and constipation. <ref name="pmid12454866">{{cite journal |vauthors=Drossman DA, Camilleri M, Mayer EA, Whitehead WE |title=AGA technical review on irritable bowel syndrome |journal=Gastroenterology |volume=123 |issue=6 |pages=2108–31 |year=2002 |pmid=12454866 |doi=10.1053/gast.2002.37095 |url=}}</ref> <ref name="pmid12241674">{{cite journal |vauthors=Talley NJ, Spiller R |title=Irritable bowel syndrome: a little understood organic bowel disease? |journal=Lancet |volume=360 |issue=9332 |pages=555–64 |year=2002 |pmid=12241674 |doi=10.1016/S0140-6736(02)09712-X |url=}}</ref> <ref name="pmid24944467">{{cite journal |vauthors=Saha L |title=Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine |journal=World J. Gastroenterol. |volume=20 |issue=22 |pages=6759–73 |year=2014 |pmid=24944467 |pmc=4051916 |doi=10.3748/wjg.v20.i22.6759 |url=}}</ref> | ||
The pathophysiology of IBS is uncertain. It has been postulated that this may be secondary to psychological causes. Yet, some patients with IBS do not have any noteworthy psychological symptoms.<ref name="pmid12454866">{{cite journal |vauthors=Drossman DA, Camilleri M, Mayer EA, Whitehead WE |title=AGA technical review on irritable bowel syndrome |journal=Gastroenterology |volume=123 |issue=6 |pages=2108–31 |year=2002 |pmid=12454866 |doi=10.1053/gast.2002.37095 |url=}}</ref><ref name="pmid12241674">{{cite journal |vauthors=Talley NJ, Spiller R |title=Irritable bowel syndrome: a little understood organic bowel disease? |journal=Lancet |volume=360 |issue=9332 |pages=555–64 |year=2002 |pmid=12241674 |doi=10.1016/S0140-6736(02)09712-X |url=}}</ref> | |||
==Genetics== | ==Genetics== | ||
Revision as of 16:43, 19 October 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Pathophysiology
IBS is a functional disorder of visceral hypersensitivity which may lead to abdominal discomfort, diarrhea and constipation. [1] [2] [3]
The pathophysiology of IBS is uncertain. It has been postulated that this may be secondary to psychological causes. Yet, some patients with IBS do not have any noteworthy psychological symptoms.[1][2]
Genetics
- [Disease name] is transmitted in [mode of genetic transmission] pattern.
- Genes involved in the pathogenesis of [disease name] include [gene1], [gene2], and [gene3].
- The development of [disease name] is the result of multiple genetic mutations.
Associated Conditions
Gross Pathology
- On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
- On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ 1.0 1.1 Drossman DA, Camilleri M, Mayer EA, Whitehead WE (2002). "AGA technical review on irritable bowel syndrome". Gastroenterology. 123 (6): 2108–31. doi:10.1053/gast.2002.37095. PMID 12454866.
- ↑ 2.0 2.1 Talley NJ, Spiller R (2002). "Irritable bowel syndrome: a little understood organic bowel disease?". Lancet. 360 (9332): 555–64. doi:10.1016/S0140-6736(02)09712-X. PMID 12241674.
- ↑ Saha L (2014). "Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine". World J. Gastroenterol. 20 (22): 6759–73. doi:10.3748/wjg.v20.i22.6759. PMC 4051916. PMID 24944467.