Toxic megacolon laboratory findings: Difference between revisions

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**[[Anemia]]
**[[Anemia]]
**[[Leukocytosis]]
**[[Leukocytosis]]
*Some patients with toxic megacolon may have elevated Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration.<ref name="BrownHaboubi2008">{{cite journal|last1=Brown|first1=S. R.|last2=Haboubi|first2=N.|last3=Hampton|first3=J.|last4=George|first4=B.|last5=Travis|first5=S. P. L.|title=The Management of Acute Severe Colitis: ACPGBI Position Statement|journal=Colorectal Disease|volume=10|year=2008|pages=8–29|issn=14628910|doi=10.1111/j.1463-1318.2008.01682.x}}</ref><ref name="pmid22131898">{{cite journal |vauthors=Strong SA |title=Management of acute colitis and toxic megacolon |journal=Clin Colon Rectal Surg |volume=23 |issue=4 |pages=274–84 |year=2010 |pmid=22131898 |pmc=3134807 |doi=10.1055/s-0030-1268254 |url=}}</ref><ref name="OrabonaValcamonico2015">{{cite journal|last1=Orabona|first1=Rossana|last2=Valcamonico|first2=Adriana|last3=Salemme|first3=Marianna|last4=Manenti|first4=Stefania|last5=Tiberio|first5=Guido AM|last6=Frusca|first6=Tiziana|title=Fulminant ulcerative colitis in a healthy pregnant woman|journal=World Journal of Gastroenterology|volume=21|issue=19|year=2015|pages=6060–6064|issn=1007-9327|doi=10.3748/wjg.v21.i19.6060}}</ref>
*Some patients with toxic megacolon may have elevated Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration.<ref name="BrownHaboubi2008">{{cite journal|last1=Brown|first1=S. R.|last2=Haboubi|first2=N.|last3=Hampton|first3=J.|last4=George|first4=B.|last5=Travis|first5=S. P. L.|title=The Management of Acute Severe Colitis: ACPGBI Position Statement|journal=Colorectal Disease|volume=10|year=2008|pages=8–29|issn=14628910|doi=10.1111/j.1463-1318.2008.01682.x}}</ref><ref name="pmid22131898">{{cite journal |vauthors=Strong SA |title=Management of acute colitis and toxic megacolon |journal=Clin Colon Rectal Surg |volume=23 |issue=4 |pages=274–84 |year=2010 |pmid=22131898 |pmc=3134807 |doi=10.1055/s-0030-1268254 |url=}}</ref><ref name="OrabonaValcamonico2015">{{cite journal|last1=Orabona|first1=Rossana|last2=Valcamonico|first2=Adriana|last3=Salemme|first3=Marianna|last4=Manenti|first4=Stefania|last5=Tiberio|first5=Guido AM|last6=Frusca|first6=Tiziana|title=Fulminant ulcerative colitis in a healthy pregnant woman|journal=World Journal of Gastroenterology|volume=21|issue=19|year=2015|pages=6060–6064|issn=1007-9327|doi=10.3748/wjg.v21.i19.6060}}</ref>11144376
*Electrolyte disturbances are common secondary to inflammatory diarrhea, steroid use and ongoing gastrointestinal losses.<ref name="pmid8282262">{{cite journal |vauthors=Panos MZ, Wood MJ, Asquith P |title=Toxic megacolon: the knee-elbow position relieves bowel distension |journal=Gut |volume=34 |issue=12 |pages=1726–7 |year=1993 |pmid=8282262 |pmc=1374472 |doi= |url=}}</ref><ref name="pmid9482465">{{cite journal |vauthors=Sheth SG, LaMont JT |title=Toxic megacolon |journal=Lancet |volume=351 |issue=9101 |pages=509–13 |year=1998 |pmid=9482465 |doi=10.1016/S0140-6736(97)10475-5 |url=}}</ref><ref>{cite book | last = Koyfman | first = Alex | title = Emergency medicine images for practice : an overview of X-ray, ultrasound, CT, and MRI images | publisher = Wolters Kluwer | location = Philadelphia | year = 2016 | isbn = 9781451192209 }}</ref>
*Electrolyte disturbances are common secondary to inflammatory diarrhea, steroid use and ongoing gastrointestinal losses.<ref name="pmid8282262">{{cite journal |vauthors=Panos MZ, Wood MJ, Asquith P |title=Toxic megacolon: the knee-elbow position relieves bowel distension |journal=Gut |volume=34 |issue=12 |pages=1726–7 |year=1993 |pmid=8282262 |pmc=1374472 |doi= |url=}}</ref><ref name="pmid9482465">{{cite journal |vauthors=Sheth SG, LaMont JT |title=Toxic megacolon |journal=Lancet |volume=351 |issue=9101 |pages=509–13 |year=1998 |pmid=9482465 |doi=10.1016/S0140-6736(97)10475-5 |url=}}</ref><ref>{cite book | last = Koyfman | first = Alex | title = Emergency medicine images for practice : an overview of X-ray, ultrasound, CT, and MRI images | publisher = Wolters Kluwer | location = Philadelphia | year = 2016 | isbn = 9781451192209 }}</ref>


Revision as of 14:56, 16 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Farima Kahe M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of toxic megacolon include anemia and leukocytosis. Some patients with toxic megacolon may have elevated concentration of ESR and CRP, which is usually suggestive of inlammation.[1]

Laboratory Findings

  • Laboratory findings consistent with the diagnosis of toxic megacolon include:[2]
  • Some patients with toxic megacolon may have elevated Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration.[3][4][5]11144376
  • Electrolyte disturbances are common secondary to inflammatory diarrhea, steroid use and ongoing gastrointestinal losses.[6][7][8]

References

  1. ↑ Autenrieth DM, Baumgart DC (2012). "Toxic megacolon". Inflamm. Bowel Dis. 18 (3): 584–91. doi:10.1002/ibd.21847. PMID 22009735.
  2. ↑ Antonopoulos P, Almyroudi M, Kolonia V, Kouris S, Troumpoukis N, Economou N (2013). "Toxic Megacolon and Acute Ischemia of the Colon due to Sigmoid Stenosis Related to Diverticulitis". Case Rep Gastroenterol. 7 (3): 409–13. doi:10.1159/000355345. PMC 3806696. PMID 24163654.
  3. ↑ Brown, S. R.; Haboubi, N.; Hampton, J.; George, B.; Travis, S. P. L. (2008). "The Management of Acute Severe Colitis: ACPGBI Position Statement". Colorectal Disease. 10: 8–29. doi:10.1111/j.1463-1318.2008.01682.x. ISSN 1462-8910.
  4. ↑ Strong SA (2010). "Management of acute colitis and toxic megacolon". Clin Colon Rectal Surg. 23 (4): 274–84. doi:10.1055/s-0030-1268254. PMC 3134807. PMID 22131898.
  5. ↑ Orabona, Rossana; Valcamonico, Adriana; Salemme, Marianna; Manenti, Stefania; Tiberio, Guido AM; Frusca, Tiziana (2015). "Fulminant ulcerative colitis in a healthy pregnant woman". World Journal of Gastroenterology. 21 (19): 6060–6064. doi:10.3748/wjg.v21.i19.6060. ISSN 1007-9327.
  6. ↑ Panos MZ, Wood MJ, Asquith P (1993). "Toxic megacolon: the knee-elbow position relieves bowel distension". Gut. 34 (12): 1726–7. PMC 1374472. PMID 8282262.
  7. ↑ Sheth SG, LaMont JT (1998). "Toxic megacolon". Lancet. 351 (9101): 509–13. doi:10.1016/S0140-6736(97)10475-5. PMID 9482465.
  8. ↑ {cite book | last = Koyfman | first = Alex | title = Emergency medicine images for practice : an overview of X-ray, ultrasound, CT, and MRI images | publisher = Wolters Kluwer | location = Philadelphia | year = 2016 | isbn = 9781451192209 }}

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