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===Discovery=== | ===Discovery=== | ||
*Toxic megacolon was first discovered by Marshak and Lester in 1950.<ref name="pmid14784154">{{cite journal |vauthors=MARSHAK RH, LESTER LJ |title=Megacolon a complication of ulcerative colitis |journal=Gastroenterology |volume=16 |issue=4 |pages=768–72 |year=1950 |pmid=14784154 |doi= |url=}}</ref> | *Toxic megacolon was first discovered by Marshak and Lester in 1950.<ref name="pmid14784154">{{cite journal |vauthors=MARSHAK RH, LESTER LJ |title=Megacolon a complication of ulcerative colitis |journal=Gastroenterology |volume=16 |issue=4 |pages=768–72 |year=1950 |pmid=14784154 |doi= |url=}}</ref> | ||
*In 1950, Marshak was the first to discover the association between [[Clostridium difficile|''Clostridium difficile'']] and the development of toxic megacolon.<ref name="Sayedy2010">{{cite journal|last1=Sayedy|first1=Leena|title=Toxic megacolon associatedClostridium difficilecolitis|journal=World Journal of Gastrointestinal Endoscopy|volume=2|issue=8|year=2010|pages=293|issn=1948-5190|doi=10.4253/wjge.v2.i8.293}}</ | *In 1950, Marshak was the first to discover the association between [[Clostridium difficile|''Clostridium difficile'']] and the development of toxic megacolon.<ref name="Sayedy2010">{{cite journal|last1=Sayedy|first1=Leena|title=Toxic megacolon associatedClostridium difficilecolitis|journal=World Journal of Gastrointestinal Endoscopy|volume=2|issue=8|year=2010|pages=293|issn=1948-5190|doi=10.4253/wjge.v2.i8.293}}</ref> | ||
==Landmark Events in the Development of Treatment Strategies== | ==Landmark Events in the Development of Treatment Strategies== | ||
Jalen criteria was developed by Jalen et al to diagnose toxic megacolon.<ref name="pmid15540290">{{cite journal |vauthors=Longo WE, Mazuski JE, Virgo KS, Lee P, Bahadursingh AN, Johnson FE |title=Outcome after colectomy for Clostridium difficile colitis |journal=Dis. Colon Rectum |volume=47 |issue=10 |pages=1620–6 |year=2004 |pmid=15540290 |doi= |url=}}</ref>ef> | Jalen criteria was developed by Jalen et al to diagnose toxic megacolon.<ref name="pmid15540290">{{cite journal |vauthors=Longo WE, Mazuski JE, Virgo KS, Lee P, Bahadursingh AN, Johnson FE |title=Outcome after colectomy for Clostridium difficile colitis |journal=Dis. Colon Rectum |volume=47 |issue=10 |pages=1620–6 |year=2004 |pmid=15540290 |doi= |url=}}</ref>ef> |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Historical Perspective
Discovery
- Toxic megacolon was first discovered by Marshak and Lester in 1950.[1]
- In 1950, Marshak was the first to discover the association between Clostridium difficile and the development of toxic megacolon.[2]
Landmark Events in the Development of Treatment Strategies
Jalen criteria was developed by Jalen et al to diagnose toxic megacolon.[3]ef>
References
- ↑ MARSHAK RH, LESTER LJ (1950). "Megacolon a complication of ulcerative colitis". Gastroenterology. 16 (4): 768–72. PMID 14784154.
- ↑ Sayedy, Leena (2010). "Toxic megacolon associatedClostridium difficilecolitis". World Journal of Gastrointestinal Endoscopy. 2 (8): 293. doi:10.4253/wjge.v2.i8.293. ISSN 1948-5190.
- ↑ Longo WE, Mazuski JE, Virgo KS, Lee P, Bahadursingh AN, Johnson FE (2004). "Outcome after colectomy for Clostridium difficile colitis". Dis. Colon Rectum. 47 (10): 1620–6. PMID 15540290.