Rhabdomyosarcoma surgery: Difference between revisions
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==Surgery== | ==Surgery== | ||
* | * Primary resection of tumor is one of the main prognostic factors in rhabdomyosarcoma.<ref name="pmid12764734">{{cite journal| author=Schalow EL, Broecker BH| title=Role of surgery in children with rhabdomyosarcoma. | journal=Med Pediatr Oncol | year= 2003 | volume= 41 | issue= 1 | pages= 1-6 | pmid=12764734 | doi=10.1002/mpo.10261 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12764734 }} </ref><ref>PDQ Pediatric Treatment Editorial Board. Childhood Rhabdomyosarcoma Treatment (PDQ®): Health Professional Version. 2019 Jan 29. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK65802/</ref> | ||
* | * Based on tumor;s location, surgical resection may be different. | ||
* | * Findings of surgical resection is essential for risk stratification. | ||
* | * Surgical tumor resection must contain complete tumor removal with performing safe margin resection. | ||
** Although recommended safety margin is 2 cm, it is impossible to perform in children because of tissue limitation.<ref name="pmid27955730">{{cite journal| author=Dasgupta R, Fuchs J, Rodeberg D| title=Rhabdomyosarcoma. | journal=Semin Pediatr Surg | year= 2016 | volume= 25 | issue= 5 | pages= 276-283 | pmid=27955730 | doi=10.1053/j.sempedsurg.2016.09.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27955730 }} </ref> | |||
** Several biopsies are needed in case of narrow margins to identify residual disease. | |||
* If surgical excision could not be performed, 12 weeks chemotherapy is recommended. | |||
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Revision as of 16:38, 15 February 2019
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Rhabdomyosarcoma Microchapters |
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Rhabdomyosarcoma surgery On the Web |
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American Roentgen Ray Society Images of Rhabdomyosarcoma surgery |
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Risk calculators and risk factors for Rhabdomyosarcoma surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Surgical resection of the rhabdomyosarcoma is often difficult or impossible because the tumor is usually embedded deep within the tissue, leaving it difficult to reach.
Surgery
- Primary resection of tumor is one of the main prognostic factors in rhabdomyosarcoma.[1][2]
- Based on tumor;s location, surgical resection may be different.
- Findings of surgical resection is essential for risk stratification.
- Surgical tumor resection must contain complete tumor removal with performing safe margin resection.
- Although recommended safety margin is 2 cm, it is impossible to perform in children because of tissue limitation.[3]
- Several biopsies are needed in case of narrow margins to identify residual disease.
- If surgical excision could not be performed, 12 weeks chemotherapy is recommended.
| Location | Symptoms |
|---|---|
| Head and neck | Wide local excision; chemotherapy +/- radiation therapy |
| Bone around the eye | Biopsy; chemotherapy + radiation therapy |
| Extremities | Wide local excision; resection of nearby lymph nodes; amputation for extensive tumors |
| Abdomen or pelvis | Neoadjvant therapy with chemotherapy and radiotherapy; wide local excision |
| Paratesticular region | Removal of testes and spermatic cord; ipsilateral retroperitoneal lymphnode resection |
References
- ↑ Schalow EL, Broecker BH (2003). "Role of surgery in children with rhabdomyosarcoma". Med Pediatr Oncol. 41 (1): 1–6. doi:10.1002/mpo.10261. PMID 12764734.
- ↑ PDQ Pediatric Treatment Editorial Board. Childhood Rhabdomyosarcoma Treatment (PDQ®): Health Professional Version. 2019 Jan 29. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK65802/
- ↑ Dasgupta R, Fuchs J, Rodeberg D (2016). "Rhabdomyosarcoma". Semin Pediatr Surg. 25 (5): 276–283. doi:10.1053/j.sempedsurg.2016.09.011. PMID 27955730.