Autoimmune hepatitis classification: Difference between revisions
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==Classification== | ==Classification== | ||
According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below:<ref name="pmid26359647">{{cite journal |vauthors=Sener AG |title=Autoantibodies in autoimmune liver diseases |journal=APMIS |volume=123 |issue=11 |pages=915–9 |year=2015 |pmid=26359647 |doi=10.1111/apm.12442 |url=}}</ref> | According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below:<ref name="pmid26359647">{{cite journal |vauthors=Sener AG |title=Autoantibodies in autoimmune liver diseases |journal=APMIS |volume=123 |issue=11 |pages=915–9 |year=2015 |pmid=26359647 |doi=10.1111/apm.12442 |url=}}</ref><ref name="pmid26341719">{{cite journal |vauthors= |title=EASL Clinical Practice Guidelines: Autoimmune hepatitis |journal=J. Hepatol. |volume=63 |issue=4 |pages=971–1004 |year=2015 |pmid=26341719 |doi=10.1016/j.jhep.2015.06.030 |url=}}</ref><ref name="pmid16984499">{{cite journal |vauthors=Floreani A, Niro G, Rosa Rizzotto E, Antoniazzi S, Ferrara F, Carderi I, Baldo V, Premoli A, Olivero F, Morello E, Durazzo M |title=Type I autoimmune hepatitis: clinical course and outcome in an Italian multicentre study |journal=Aliment. Pharmacol. Ther. |volume=24 |issue=7 |pages=1051–7 |year=2006 |pmid=16984499 |doi=10.1111/j.1365-2036.2006.03104.x |url=}}</ref> | ||
*Autoimmune hepatitis Type-1: | |||
**Common type of AIH (accounts almost for 90% of AIH cases) | **Common type of AIH (accounts almost for 90% of AIH cases) | ||
**Presents at any age | **Presents at any age | ||
Revision as of 19:12, 5 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ;Manpreet Kaur, MD [2]
Overview
Classification
According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below:[1][2][3]
- Autoimmune hepatitis Type-1:
- Common type of AIH (accounts almost for 90% of AIH cases)
- Presents at any age
- Antibodies like ANA(antinuclear antibodies), SMA(smooth muscle antibodies) or anti-SLA/LP(soluble liver antigen/liver pancreas antibodies) can be detected
- Association with HLA(human leukocyte antigens)DR3, DR4, and DR13
- Treatment failure is rare but relapse occur after withdrawal of treatment and long-term maintenance therapy is given
- Autoimmune hepatitis Type 2:
- Accounts for 10% of AIH cases
- Presents usually in childhood and young adulthood
- Antibodies like anti-LKM1(liver/kidney microsomal antibody type 1), anti-LC1(antibodies against liver cytosol type 1 antigen) and rarely anti-LKM3(liver/kidney microsomal antibody type 3) can be detected
- Association with HLA DR3 and DR7
- Treatment failure is common and frequent relapse rates after withdrawal of treatment and long-term maintenance therapy commonly advised
- Autoimmune hepatitis Type 3:
- AIH type 3 is similar to AIH type 1 but presents more severe.
- SLA/LP(soluble liver antigen/liver pancreas antibodies) is detected
- Ro52-antibody positive
References
- ↑ Sener AG (2015). "Autoantibodies in autoimmune liver diseases". APMIS. 123 (11): 915–9. doi:10.1111/apm.12442. PMID 26359647.
- ↑ "EASL Clinical Practice Guidelines: Autoimmune hepatitis". J. Hepatol. 63 (4): 971–1004. 2015. doi:10.1016/j.jhep.2015.06.030. PMID 26341719.
- ↑ Floreani A, Niro G, Rosa Rizzotto E, Antoniazzi S, Ferrara F, Carderi I, Baldo V, Premoli A, Olivero F, Morello E, Durazzo M (2006). "Type I autoimmune hepatitis: clinical course and outcome in an Italian multicentre study". Aliment. Pharmacol. Ther. 24 (7): 1051–7. doi:10.1111/j.1365-2036.2006.03104.x. PMID 16984499.