Autoimmune hepatitis laboratory findings

Autoimmune hepatitis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating autoimmune hepatitis differential diagnosis
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Diagnostic of choice
Laboratory Findings
Electrocardiogram
X Ray
CT
MRI
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Autoimmune hepatitis laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Autoimmune hepatitis laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Autoimmune hepatitis laboratory findings
CDC on Autoimmune hepatitis laboratory findings
Autoimmune hepatitis laboratory findings in the news
Blogs on Autoimmune hepatitis laboratory findings
Directions to Hospitals Treating Autoimmune hepatitis
Risk calculators and risk factors for Autoimmune hepatitis laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  :Manpreet Kaur, MD [2]

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Following laboratory tests are used to diagnose autoimmune hepatitis:

• Liver function tests
• Alkaline phosphatase
• Antibody assays
• Serum protein and immunoglobulins
• Complete blood count and differential count
• Platelet count
• ESR
• Coombs test
• Peripheral blood film

Laboratory findings consistent with the diagnosis of Autoimmune hepatitis include:

• Increased serum aminotransferase levels (1.5-50 times reference values)
• Increased serum immunoglobulin levels, primarily immunoglobulin G (1.2 to 3.0 times normal)
• Seropositive for ANAs, anti-actin, SMAs, LKM-1, anti-liver cytosol 1 (anti-LC1) antibodies, SLA/LP autoantibodies or pANCA

Revised Original Scoring System of the International Autoimmune Hepatitis Group
Laboratory Findings	Points
AP:AST (or ALT) ratio <1.5 1.5-3	+2 0 -2