Splenic vein thrombosis pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
== Pathophysiology== | == Pathophysiology== | ||
Splenic vein thrombosis in acute or chronic pancreatitis results | |||
from perivenous inflammation caused by the anatomic location of | |||
the splenic vein along the entire posterior aspect of the pancreatic | |||
tail, where it lies in direct contact with the peripancreatic inflammatory | |||
tissue. The exact mechanism of thrombosis is likely multifactorial, | |||
including both intrinsic endothelial damage from inflammatory | |||
or neoplastic processes and extrinsic damage secondary to | |||
venous compression from fibrosis, adjacent pseudocysts, or edema | |||
[1]. Obstruction of the splenic vein may also be caused by enlarged | |||
retroperitoneal lymph nodes or by pancreatic or perisplenic nodes | |||
that are located near the splenic artery, superior to the splenic vein. | |||
These nodes lie adjacent to the pancreas and splenic vein and compress | |||
compress | |||
the splenic vein when involved in an inflammatory or neoplastic | |||
process | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 14:57, 20 December 2017
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Splenic vein thrombosis Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Splenic vein thrombosis pathophysiology On the Web |
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American Roentgen Ray Society Images of Splenic vein thrombosis pathophysiology |
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Risk calculators and risk factors for Splenic vein thrombosis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
Pathophysiology
Splenic vein thrombosis in acute or chronic pancreatitis results from perivenous inflammation caused by the anatomic location of the splenic vein along the entire posterior aspect of the pancreatic tail, where it lies in direct contact with the peripancreatic inflammatory tissue. The exact mechanism of thrombosis is likely multifactorial, including both intrinsic endothelial damage from inflammatory or neoplastic processes and extrinsic damage secondary to venous compression from fibrosis, adjacent pseudocysts, or edema [1]. Obstruction of the splenic vein may also be caused by enlarged retroperitoneal lymph nodes or by pancreatic or perisplenic nodes that are located near the splenic artery, superior to the splenic vein. These nodes lie adjacent to the pancreas and splenic vein and compress compress the splenic vein when involved in an inflammatory or neoplastic process